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A win in protection against ischemia-reperfusion injury?

Published byMadalena Klettenberg Mendonça Modified over 5 years ago

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Presentation on theme: "A win in protection against ischemia-reperfusion injury?"— Presentation transcript:

1 A win in protection against ischemia-reperfusion injury?
Tyson A. Fricke, MBBS, BMedSci, Igor E. Konstantinov, MD, PhD, FRACS  The Journal of Thoracic and Cardiovascular Surgery  DOI: /j.jtcvs Copyright © Terms and Conditions

2 Figure 1 Pathways of cannabinoid receptor-mediated protection against ischemia-reperfusion (IR) injury. Cannabinoid receptor ligand (WIN ) binding to cannabinoid receptors may reduce apoptosis and decrease proinflammatory cytokines and nitric oxide (NO) by increasing cytosolic inhibitory kBα, thus decreasing nuclear translocation of nuclear factor-kB (NF-kB) and decreasing nuclear translocation of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/Siah1 complex. CB1, Cannabinoid receptor 1; CB2, cannabinoid receptor 2; IkBα, inhibitory kBα; iNOS, inducible nitric oxide synthase; ROS, reactive oxygen species. The Journal of Thoracic and Cardiovascular Surgery DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

3 Igor E. Konstantinov, MD, PhD, FRACS, and Tyson A
Igor E. Konstantinov, MD, PhD, FRACS, and Tyson A. Fricke, MBBS, BMedSci The Journal of Thoracic and Cardiovascular Surgery DOI: ( /j.jtcvs ) Copyright © Terms and Conditions

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