Martin Bødtker Mortensen, and Erling Falk JACC 2018;71:85-94 Conceptual Relationship Between Age and Absolute Benefit of Statin Therapy Calculations based on the pooled cohort equations assuming a population of nonsmoking men with systolic blood pressure 135 mm Hg, total cholesterol 232 mg/dl, and high-density lipoprotein (HDL) cholesterol 37 mg/dl without diabetes or hypertension. (Top) Estimated 10-year risk for atherosclerotic cardiovascular disease (ASCVD) before and after statin therapy assuming 40% and 20% relative risk reduction (RRR). (Middle) The absolute risk reduction with statins increases substantially with age. (Bottom) The number needed to treat (NNT) in 5 years to prevent 1 ASCVD event becomes lower with aging, even in case of lower efficacy of treatment. Martin Bødtker Mortensen, and Erling Falk JACC 2018;71:85-94 2018 The Authors