And the Noise Played on: Stochastic Gene Expression and HIV-1 Infection  William J. Blake, James J. Collins  Cell  Volume 122, Issue 2, Pages 147-149 (July 2005) DOI: 10.1016/j.cell.2005.07.006 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 The Tat Transactivation-Positive Feedback Loop Stochastic fluctuations in the production of the HIV-1 Tat protein within a model positive feedback loop (LTR-GFP-IRES-Tat) result in two distinct phenotypes. Cells that, by chance, exhibit a large burst of Tat protein production initiate the Tat transactivation loop leading to the production of high levels of Tat protein, corresponding to productive HIV-1 infection. Alternatively, in other cells, basal levels of Tat protein production may not be sufficient to initiate the positive feedback loop, corresponding to latent HIV-1 infection. Cell 2005 122, 147-149DOI: (10.1016/j.cell.2005.07.006) Copyright © 2005 Elsevier Inc. Terms and Conditions