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Rewiring Bacteria, Two Components at a Time

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Presentation on theme: "Rewiring Bacteria, Two Components at a Time"— Presentation transcript:

1 Rewiring Bacteria, Two Components at a Time
Michael A. Kohanski, James J. Collins  Cell  Volume 133, Issue 6, Pages (June 2008) DOI: /j.cell Copyright © 2008 Elsevier Inc. Terms and Conditions

2 Figure 1 Rewiring a Bacterial Two-Component System
(Top) Shown is the native EnvZ-OmpR two-component signal transduction system (red) from the bacteria Escherichia coli for sensing and responding to osmolarity changes. (Bottom) A theoretical EnvZ sensor (red) rewired for chemotaxis pathway (CheA-CheY; blue) specificity, which still senses osmolarity changes but responds by initiating expression of chemotaxis genes. Cell  , DOI: ( /j.cell ) Copyright © 2008 Elsevier Inc. Terms and Conditions

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