Ribosomal Architecture: Constraints Imposed by the Need for Self-Production  Jeffrey A. Hussmann, Hendrik Osadnik, Carol A. Gross  Current Biology  Volume 27, Issue 16, Pages R798-R800 (August 2017) DOI: 10.1016/j.cub.2017.06.080 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Splitting ribosomal protein content into small units leads to a faster return on investment in ribosome production. If ribosomal protein is organized as one long peptide (top), substantial time passes between beginning to translate the peptide (t0) and completing the protein component of a functional ribosome (t2). Splitting protein content into smaller peptides (bottom) allows these components to be made in parallel and assembled into a functional ribosome at an earlier time point (t1), after which this new ribosome can begin contributing to translation. Current Biology 2017 27, R798-R800DOI: (10.1016/j.cub.2017.06.080) Copyright © 2017 Elsevier Ltd Terms and Conditions