Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs McDermott Niamh , Meunier Armelle , Wong Simon , Buchete.

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Profiling of a panel of radioresistant prostate cancer cells identifies deregulation of key miRNAs McDermott Niamh , Meunier Armelle , Wong Simon , Buchete Vio , Marignol Laure Clinical and Translational Radiation Oncology Volume 2, Pages 63-68 (February 2017) DOI: 10.1016/j.ctro.2017.01.005 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Radiation survival curves and miRNA profiling of the 22Rv1 cell lines panel. Surviving fraction of the radiation resistant (RR-22RV1), wild type (WT-22RV1), 22Rv1 age matched control (AMC-22RV1) and hypoxic (H-22Rv1) cells in response to single radiation doses of up to 6Gy. Mean±SEM, *p⩽0.05. Clinical and Translational Radiation Oncology 2017 2, 63-68DOI: (10.1016/j.ctro.2017.01.005) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Schematic representation of miRNAs profiles analysis. Clinical and Translational Radiation Oncology 2017 2, 63-68DOI: (10.1016/j.ctro.2017.01.005) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Validation of miR-210 and miR-4284 expression patterns in radioresistant 22Rv1 cells. Fold change in mRNA expression of (A) miR-201 and (B) miR-4284 in RR-22Rv1, AMC-22Rv1 and H-22Rv1 relative to WT-22Rv1 cells. Clinical and Translational Radiation Oncology 2017 2, 63-68DOI: (10.1016/j.ctro.2017.01.005) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 Correlation between miR-4284 expression and target gene expression. The fold change in miR-4284 expression following transfection of 22Rv1 cells with a miR-4284 mimic when compared to untransfected controls are plotted against the measured fold change in expression of predicted miR-4284 target genes in individual sample replicates. The relationship was analysed using a Pearson correlation: Pearson r coefficient and R2 values are presented. Clinical and Translational Radiation Oncology 2017 2, 63-68DOI: (10.1016/j.ctro.2017.01.005) Copyright © 2017 The Authors Terms and Conditions