Repeated implantation failure at the crossroad between statistics, clinics and over- diagnosis Edgardo Somigliana, Paola Vigano, Andrea Busnelli, Alessio.

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Presentation transcript:

Repeated implantation failure at the crossroad between statistics, clinics and over- diagnosis Edgardo Somigliana, Paola Vigano, Andrea Busnelli, Alessio Paffoni, Walter Vegetti, Paolo Vercellini Reproductive BioMedicine Online Volume 36, Issue 1, Pages 32-38 (January 2018) DOI: 10.1016/j.rbmo.2017.09.012 Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Relationship between pregnancy rate and rate of repeated implantation failure (RIF). According to the basal assumptions of the model, the prevalence of RIF and the chance of pregnancy in the no-RIF population were constant and set at 10% and 30%, respectively. The upper panel shows the chances of pregnancy per cycle according to the number of attempts. The lower panel illustrated the cumulative chances of pregnancy with the number of attempts. Reproductive BioMedicine Online 2018 36, 32-38DOI: (10.1016/j.rbmo.2017.09.012) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Results from the two sensitivity analyses on the rate of IVF success and on the prevalence of repeated implantation failure (RIF). Five different rates were assessed for the two considered variables. In the upper panel, the rate of success of IVF was modified from 10% to 50%. In the lower panel the prevalence of RIF was modified from 5 to 25%. CPR, clinial pregnancy rate; ICSI, intracytoplasmic sperm injection. Reproductive BioMedicine Online 2018 36, 32-38DOI: (10.1016/j.rbmo.2017.09.012) Copyright © 2017 Reproductive Healthcare Ltd. Terms and Conditions