The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: A protein array study Rachel K. Middleton, BSc,

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Presentation transcript:

The pro-inflammatory and chemotactic cytokine microenvironment of the abdominal aortic aneurysm wall: A protein array study Rachel K. Middleton, BSc, Geraint M. Lloyd, MRCS, Matthew J. Bown, MD, Nicola J. Cooper, PhD, Nicholas J. London, MD, Robert D. Sayers, MD Journal of Vascular Surgery Volume 45, Issue 3, Pages 574-580 (March 2007) DOI: 10.1016/j.jvs.2006.11.020 Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 1 Box plots show the expression of the (A) CXC chemokines (ENA-78, epithelial neutrophil activating peptide-78; GRO, growth regulated oncogene; IL-8, interleukin-8; MIG, monokine-induced by interferon-γ; SDF-1, stromal cell derived factor-1) and (B) the CC chemokines (MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIP-1δ, macrophage inflammatory protein-1δ; RANTES, regulated upon activation, normal T-cell expressed and secreted; TARC, thymus and activation-regulated chemokine). The interquartile range (box) and median (internal bar within the box) signal intensity values in abdominal aortic aneurysm (AAA) (n = 10) and control (n = 9) samples are displayed for each cytokine. The whiskers display the range of values. Mann-Whitney analysis was performed for each cytokine and the results with a significant P value (P < .01) are displayed on the graph. Journal of Vascular Surgery 2007 45, 574-580DOI: (10.1016/j.jvs.2006.11.020) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 2 Box plots show the expression of the (A) pro-inflammatory (IL, interleukin; IFN-γ, interferon-γ; TNF, tumor necrosis factor; OSM, oncostatin M) and (B) anti-inflammatory cytokines (IL, interleukin). The interquartile range (box) and median (internal bar within the box) signal intensity values in abdominal aortic aneurysm (AAA) (n = 10) and control (n = 9) samples are displayed for each cytokine. The whiskers display the range of values. Mann-Whitney analysis was performed for each cytokine and the results with a significant P value (P < .01) are displayed on the graph. Journal of Vascular Surgery 2007 45, 574-580DOI: (10.1016/j.jvs.2006.11.020) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

Fig 3 A and B, The expression of the growth factors from the arrays are shown in the box plots. The interquartile range (box) and median (internal bar within the box) signal intensity values in abdominal aortic aneurysm (AAA) (n = 10) and control (n = 9) samples are displayed for each cytokine. The whiskers display the range of values. Mann-Whitney analysis was performed for each cytokine and the results with a significant P value (P < .01) are displayed on the graph (GCSF, granulocyte colony-stimulating factor; GM-CSF, granulocyte/macrophage colony-stimulating factor; MCSF, macrophage colony-stimulating factor; SCF, stem cell factor; VEGF, vascular endothelial growth factor; PDGF-β, platelet-derived growth factor-β; EGF, epidermal growth factor; IGF-1, insulin-like growth factor-1; TGF-β1, transforming growth factor-β1; IL, interleukin; Ang, angiogenin; Tpo, thrombopoietin). Journal of Vascular Surgery 2007 45, 574-580DOI: (10.1016/j.jvs.2006.11.020) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions