Frances Busfield, David L. Duffy, Janine B. Kesting, Shelley M

Slides:



Advertisements
Similar presentations
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Advertisements

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
Refinement of the Chromosome 5p Locus for Familial Calcium Pyrophosphate Dihydrate Deposition Disease  L.J. Andrew, V. Brancolini, L. Serrano de la Pena,
Quantitative-Trait-Locus Analysis of Body-Mass Index and of Stature, by Combined Analysis of Genome Scans of Five Finnish Study Groups  Markus Perola,
A New Locus for Autosomal Recessive Hereditary Spastic Paraplegia Maps to Chromosome 16q24.3  Giuseppe De Michele, Maurizio De Fusco, Francesca Cavalcanti,
Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism  Laura Almasy, James E. Hixson,
The Gene for Glycogen-Storage Disease Type 1b Maps to Chromosome 11q23
Genomewide Linkage Analysis Identifies Polymorphism in the Human Interferon-γ Receptor Affecting Helicobacter pylori Infection  Thorsten Thye, Gerd D.
Identification of a Major Susceptibility Locus for Restless Legs Syndrome on Chromosome 12q  Alex Desautels, Gustavo Turecki, Jacques Montplaisir, Adolfo.
Transmission/Disequilibrium Tests for Extended Marker Haplotypes
Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity  Kathrin Saar, Lihadh.
Genetic Linkage of Paget Disease of the Bone to Chromosome 18q
Localization of a Gene (MCUL1) for Multiple Cutaneous Leiomyomata and Uterine Fibroids to Chromosome 1q42.3-q43  N.A. Alam, S. Bevan, M. Churchman, E.
Use of Homozygosity Mapping to Identify a Region on Chromosome 1 Bearing a Defective Gene That Causes Autosomal Recessive Homozygous Hypercholesterolemia.
Soraya Beiraghi, Swapan K. Nath, Matthew Gaines, Desh D
Genomewide Linkage Scan Identifies a Novel Susceptibility Locus for Restless Legs Syndrome on Chromosome 9p  Shenghan Chen, William G. Ondo, Shaoqi Rao,
Genomewide Linkage Scan for Myopia Susceptibility Loci among Ashkenazi Jewish Families Shows Evidence of Linkage on Chromosome 22q12  Dwight Stambolian,
Genomewide Search for Type 2 Diabetes–Susceptibility Genes in French Whites: Evidence for a Novel Susceptibility Locus for Early-Onset Diabetes on Chromosome.
A Combined Linkage-Physical Map of the Human Genome
The Gene for Glycogen-Storage Disease Type 1b Maps to Chromosome 11q23
Tamara Rogers, David Chandler, Dora Angelicheva, P. K
Use of Closely Related Affected Individuals for the Genetic Study of Complex Diseases in Founder Populations  C. Bourgain, E. Génin, P. Holopainen, K.
The American Journal of Human Genetics 
Attention-Deficit/Hyperactivity Disorder in a Population Isolate: Linkage to Loci at 4q13.2, 5q33.3, 11q22, and 17p11  Mauricio Arcos-Burgos, F. Xavier.
Elizabeth Theusch, Analabha Basu, Jane Gitschier 
Ehlers-Danlos Syndrome with Severe Early-Onset Periodontal Disease (EDS-VIII) Is a Distinct, Heterogeneous Disorder with One Predisposition Gene at Chromosome.
Evidence for a Nonallelic Heterogeneity of Epidermodysplasia Verruciformis with Two Susceptibility Loci Mapped to Chromosome Regions 2p21–p24 and 17q25 
Susceptibility Loci for Preeclampsia on Chromosomes 2p25 and 9p13 in Finnish Families  Hannele Laivuori, Päivi Lahermo, Vesa Ollikainen, Elisabeth Widen,
Howard B. Yeon, Noralane M. Lindor, J.G. Seidman, Christine E. Seidman 
Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4
Tristan F. W. McMullan, Andrew R. Collins, Anthony G. Tyers, David O
Familial Juvenile Hyperuricemic Nephropathy: Localization of the Gene on Chromosome 16p11.2—and Evidence for Genetic Heterogeneity  Blanka Stibůrková,
The Gene for Human Fibronectin Glomerulopathy Maps to 1q32, in the Region of the Regulation of Complement Activation Gene Cluster  Martin Vollmer, Martin.
Two Families with Familial Amyotrophic Lateral Sclerosis Are Linked to a Novel Locus on Chromosome 16q  Deborah M. Ruddy, Matthew J. Parton, Ammar Al-Chalabi,
The Gene for Naegeli–Franceschetti–Jadassohn Syndrome Maps to 17q21
A Genomewide Search Finds Major Susceptibility Loci for Nicotine Dependence on Chromosome 10 in African Americans  Ming D. Li, Thomas J. Payne, Jennie.
A Locus for Hereditary Sensory Neuropathy with Cough and Gastroesophageal Reflux on Chromosome 3p22-p24  C. Kok, M.L. Kennerson, P.J. Spring, A.J. Ing,
Localization of a Gene for Benign Adult Familial Myoclonic Epilepsy to Chromosome 8q23.3-q24.1  Masaaki Mikami, Takeshi Yasuda, Akira Terao, Masayuki.
Hal M. Hoffman, Fred A. Wright, David H. Broide, Alan A
Mapping of Charcot-Marie-Tooth Disease Type 1C to Chromosome 16p Identifies a Novel Locus for Demyelinating Neuropathies  Valerie A. Street, Jeff D. Goldy,
E. Warwick Daw, Simon C. Heath, Ellen M. Wijsman 
Koji Suzuki, Tania Bustos, Richard A. Spritz 
Erratum The American Journal of Human Genetics
A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes  Hong-Wen Deng, Hongyi Deng, Yong-Jun Liu, Yao-Zhong Liu, Fu-Hua Xu, Hui Shen,
Linkage Analysis Identifies a Novel Locus for Restless Legs Syndrome on Chromosome 2q in a South Tyrolean Population Isolate  Irene Pichler, Fabio Marroni,
Shwachman-Diamond Syndrome with Exocrine Pancreatic Dysfunction and Bone Marrow Failure Maps to the Centromeric Region of Chromosome 7  Sharan Goobie,
Genetic Linkage of Autosomal-Dominant Alport Syndrome with Leukocyte Inclusions and Macrothrombocytopenia (Fechtner Syndrome) to Chromosome 22q11-13 
On a Randomization Procedure in Linkage Analysis
John A. Martignetti, Karen E
A Severely Affected Male Born into a Rett Syndrome Kindred Supports X-Linked Inheritance and Allows Extension of the Exclusion Map  Carolyn Schanen, Uta.
Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease  Edwin K. Silverman, Lyle.
Evidence That the Penetrance of Mutations at the RP11 Locus Causing Dominant Retinitis Pigmentosa Is Influenced by a Gene Linked to the Homologous RP11.
A Genomewide Search Using an Original Pairwise Sampling Approach for Large Genealogies Identifies a New Locus for Total and Low-Density Lipoprotein Cholesterol.
The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval  Alexander Zimprich,
A Gene for Fluctuating, Progressive Autosomal Dominant Nonsyndromic Hearing Loss, DFNA16, Maps to Chromosome 2q   Kunihiro Fukushima, Norio Kasai,
Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications 
Hereditary Isolated Renal Magnesium Loss Maps to Chromosome 11q23
A New Locus for Autosomal Recessive Hypercholesterolemia Maps to Human Chromosome 15q25-q26  Milco Ciccarese, Adolfo Pacifico, Giancarlo Tonolo, Paolo.
Genome Screen to Identify Susceptibility Genes for Parkinson Disease in a Sample without parkin Mutations  Nathan Pankratz, William C. Nichols, Sean K.
A Gene for an Autosomal Dominant Scleroatrophic Syndrome Predisposing to Skin Cancer (Huriez Syndrome) Maps to Chromosome 4q23  Young-Ae Lee, Howard P.
Simone Sanna-Cherchi, Gianluca Caridi, Patricia L
A Gene for Autosomal Recessive Spondylocostal Dysostosis Maps to 19q13
Alice S. Whittemore, Jerry Halpern 
Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity  Kathrin Saar, Lihadh.
A Chromosomal Deletion Map of Human Malformations
A Locus for Autosomal Dominant Hereditary Spastic Ataxia, SAX1,Maps to Chromosome 12p13  I.A. Meijer, C.K. Hand, K.K. Grewal, M.G. Stefanelli, E.J. Ives,
Mapping of a New SGBS Locus to Chromosome Xp22 in a Family with a Severe Form of Simpson-Golabi-Behmel Syndrome  L.M. Brzustowicz, S. Farrell, M.B. Khan,
Genomewide Comparison of DNA Sequences between Humans and Chimpanzees
Autosomal Recessive Cerebellar Ataxia with Oculomotor Apraxia (Ataxia- Telangiectasia–Like Syndrome) Is Linked to Chromosome 9q34  Andrea H. Németh, Elena.
Linkage of Familial Hemophagocytic Lymphohistiocytosis to 10q21-22 and Evidence for Heterogeneity  Rémi Dufourcq-Lagelouse, Nada Jabado, Françoise Le.
Presentation transcript:

A Genomewide Search for Type 2 Diabetes–Susceptibility Genes in Indigenous Australians  Frances Busfield, David L. Duffy, Janine B. Kesting, Shelley M. Walker, Paul K. Lovelock, David Good, Heather Tate, Denise Watego, Maureen Marczak, Noel Hayman, Joanne T.E. Shaw  The American Journal of Human Genetics  Volume 70, Issue 2, Pages 349-357 (February 2002) DOI: 10.1086/338626 Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree structure. Blackened symbols denote individuals with type II diabetes. Unblackened symbols denote unaffected individuals. The arrow indicates the proband. The American Journal of Human Genetics 2002 70, 349-357DOI: (10.1086/338626) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 2 Graphs of two-point LOD scores at θ=0.01, for each autosome from the genomewide scan. The x-axes represent distance in centimorgans, and the y-axes represent two-point LOD scores. The American Journal of Human Genetics 2002 70, 349-357DOI: (10.1086/338626) Copyright © 2002 The American Society of Human Genetics Terms and Conditions

Figure 3 Graph of multipoint LOD scores for chromosome 2q. Marker positions are sex-averaged and are calculated on the basis of The Genetic Location Database. The American Journal of Human Genetics 2002 70, 349-357DOI: (10.1086/338626) Copyright © 2002 The American Society of Human Genetics Terms and Conditions