Groupe de travail athérosclérose 1 STULONG Discovery Challenges Feedback Marie Tomečková EuroMISE – Cardio This work is supported by the project LN00B107 of the Ministry of Education of the Czech Republic

Groupe de travail athérosclérose2 STULONG Challenges – Medical feedback STULONG = acronym LONGitudinal STUdy Main aims of the study: To determine prevalence of the risk factors of atherosclerosis in middle-age men To follow up the development of the risk factors To follow up the development of the risk factors To asses the possibilities and the influence of the complex intervention on the incidence and values of the risk factors and on the cardiovascular mortality To asses the possibilities and the influence of the complex intervention on the incidence and values of the risk factors and on the cardiovascular mortality

Groupe de travail athérosclérose3 Atherosclerosis: a total complicated disease of all over organism a dynamic process, it begins in childhood and adolescence and continues for the whole life opinions on the origin and progress of the disease are developing interaction and influence of genetic predisposition and exterior environment the influence of so-called risk factors is still regarded some so-called protective factors exist

Groupe de travail athérosclérose4 STULONG - analysis Statistical - descriptive statistics - logistic regression - survival analysis Data mining - different methods - resulting in different conclusions

Prevalence of risk factors in RG

Mortality caused by atherosclerotic CVD

Mortality caused by atherosclerotic CVD depending on the number of RFA

Kaplan-Meier analysis in RG (at age of years) depending on the number of RFA

Kaplan-Meier analysis in RG (at age of years) depending on the number of RFA

The relative risk of death caused by other. CVD

Groupe de travail athérosclérose11 univaried and bivaried data analysis univaried and bivaried data analysis association rules association rules trend analysis trend analysis analysis so called time windows analysis so called time windows ROC analysis ROC analysis Miner tool SDS, WEKA tool, STATISTICA tool Miner tool SDS, WEKA tool, STATISTICA tool genetic approach genetic approach standard attribute-value data mining techniques standard attribute-value data mining techniques inductive logic programming technique inductive logic programming technique Different approaches to solve the analytic questions

Groupe de travail athérosclérose12 Different approaches to solve the analytic questions – continue: fuzzy approximate dependencies fuzzy approximate dependencies explicit relations - functional dependencies explicit relations - functional dependencies the inductive logic programming technique the inductive logic programming technique Rough Set Exploration System to solve both classification and descriptive tasks Rough Set Exploration System to solve both classification and descriptive tasks approach to generate a mathematical algebraic model – discriminate function - Werner, Kalganova approach to generate a mathematical algebraic model – discriminate function - Werner, Kalganova the selection of = interesting = emerging patterns (strong emerging patterns the selection of = interesting = emerging patterns (strong emerging patterns

Groupe de travail athérosclérose13 Challenge 2003 Some approaches to solve the analytic questions Genetic approach – function based on the Area Under the ROC curve - Conclusions very good understanable Azé,J. - Lucas,N. - Sebag,M.: A New Medical Test for Atherosclerosis Detection GeNo Fuzzy Approximate Dependencies – Fuzzy logic – Interesting relations – for discussion Berzal,F. - Cubero,J.C.- Sanchez,D. - Serrano,J.M. - Vila,M.A.: Finding Fuzzy Approximate Dependencies within STULONG Data

Groupe de travail athérosclérose14 Challenge 2003 – cont. Some approaches to solve the analytic questions Association rules – see later (Prague) Burian,J. - Rauch,J.: Analysis of Death Causes in the STULONG Data Set Strongest Emerging Patterns – very interesting approach, results to discuss Cremilleux,B.- Soulet,A. - Rioult,F.: Mining the Strongest Emerging Patterns Characterizing Patients Affected by Diseases Due to Atherosclerosis Rough Set Exploration System (RSES) – experimental tool, not yet implemented, without explications Hoa,N.S. - Son,N.H.: Analysis of STULONG Data by Rough Set Exploration System (RSES)

Groupe de travail athérosclérose15 Challenge 2003 – cont. Some approaches to solve the analytic questions SDS rules (Set Differs of Set) – some very interesting results – diferences among the groups in more than two variables – good conclusions Karban,T.: SDS-Rules and Classification on PKDD2003 Discovery Challenge Trend analysis, analysis so called time windows - interesting approache, some conlusiones to discuss from medical point of view Novakova,L. - Klema,J. - Jakob,M.- Rawles,S. - Stepankova,O.: Trend Analysis and Risk Identification

Groupe de travail athérosclérose16 Challenge 2003 – cont. Some approaches to solve the analytic questions WEKA tool, ACE data tool – very good presentation with ilustrative explanations Van Assche,A. - Verbaeten,S. - Krzywania,D. - Struyf,J. - Blockeel,H.: Attribute-Value and First Order Data Mining within the STULONG Project Discriminate function Discriminate function Werner,J.C. - Kalganova,T.: Risk Evaluation using Evolvable Discriminate Function