Modified Rankin score 0-2

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Modified Rankin score 0-2 EXTEND-IA Trial design: Patients with acute ischemic stroke presenting within 4.5 hours of symptom onset were randomized to endovascular thrombectomy with the Solitaire FR stent retriever + intravenous alteplase or intravenous alteplase alone. They were followed for 90 days. Results (p = 0.01) Primary outcome: Perfusion at 24 hours for endovascular + alteplase group vs. alteplase: 100% vs. 37%, p < 0.0001 Modified Rankin score of 0-2: 71% vs. 40%; p = 0.01 Symptomatic ICH: 0% vs. 6%, p = 0.49; mortality: 9.0% vs. 20.0%, p = 0.18 % Conclusions Among patients with acute ischemic stroke due to proximal large arterial occlusion, endovascular treatment + intravenous thrombolysis is superior to intravenous thrombolysis alone in improving perfusion, neurological, and functional outcomes In line with other recent trials suggesting benefit with endovascular therapy; may change practice Modified Rankin score 0-2 Endovascular + IV alteplase (n = 35) IV alteplase (n = 35) Campbell BC, et al. N Engl J Med 2015;372:1009-18