David Myerson, Gideon Steinbach, Ted A. Gooley, Howard M. Shulman

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Presentation transcript:

Graft-versus-Host Disease of the Gut: A Histologic Activity Grading System and Validation David Myerson, Gideon Steinbach, Ted A. Gooley, Howard M. Shulman Biology of Blood and Marrow Transplantation Volume 23, Issue 9, Pages 1573-1579 (September 2017) DOI: 10.1016/j.bbmt.2017.05.017 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Biology of Blood and Marrow Transplantation 2017 23, 1573-1579DOI: (10 Biology of Blood and Marrow Transplantation 2017 23, 1573-1579DOI: (10.1016/j.bbmt.2017.05.017) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Apoptotic cells per section (plotted on a log scale) versus activity grade. (solid line, ■) Scale comprises grades 1, 2, 3, and 4. (dotted line, ◆) Scale comprises grades 1, 2A, 2B, 3, and 4. The former 2 is divided into low (2A) and high (2B). This shows the grading scale with 2A and 2B with more equally spaced ratios, appearing as more of a straight line on the log plot. Biology of Blood and Marrow Transplantation 2017 23, 1573-1579DOI: (10.1016/j.bbmt.2017.05.017) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Distribution of activity grades found in all specimens. Biology of Blood and Marrow Transplantation 2017 23, 1573-1579DOI: (10.1016/j.bbmt.2017.05.017) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Marimekko chart showing relation between activity grade and change in therapy for all specimen sites, and within the black rectangular outline, the subset of specimens with activity grades 1, 2, 3, and 4. The area reflects number of specimens in each activity grade or therapeutic change category. Biology of Blood and Marrow Transplantation 2017 23, 1573-1579DOI: (10.1016/j.bbmt.2017.05.017) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions