Neeru Bhardwaj, John M. Coffin Cell Host & Microbe

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Endogenous Retroviruses and Human Cancer: Is There Anything to the Rumors? Neeru Bhardwaj, John M. Coffin Cell Host & Microbe Volume 15, Issue 3, Pages 255-259 (March 2014) DOI: 10.1016/j.chom.2014.02.013 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Recombinant Origin of XMRV The uninfected CWR22 tumor was passaged serially in nude mice. Sometime prior to 1996, the xenograft was infected by an infectious recombinant derived from the two noninfectious XMLVs preXMRV-1 and preXMRV-2. In 1992, the 22rv1 cell line was derived from this tumor and has been passaged in culture ever since. This image is reprinted with permission from Delviks-Frankenberry et al. (2012). Cell Host & Microbe 2014 15, 255-259DOI: (10.1016/j.chom.2014.02.013) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 2 HERV-K (HML-2) and Primate Evolution Syncytins are env genes encoded by other retrovirus groups that have been co-opted by their mammalian host for use in normal placenta formation. Virus image reprinted with permission from Kurth and Bannert (2010). Scale bar, 100 nm. Cell Host & Microbe 2014 15, 255-259DOI: (10.1016/j.chom.2014.02.013) Copyright © 2014 Elsevier Inc. Terms and Conditions