Common Single-Nucleotide Polymorphisms Act in Concert to Affect Plasma Levels of High-Density Lipoprotein Cholesterol Victor Spirin, Steffen Schmidt,

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Common Single-Nucleotide Polymorphisms Act in Concert to Affect Plasma Levels of High-Density Lipoprotein Cholesterol Victor Spirin, Steffen Schmidt, Alexander Pertsemlidis, Richard S. Cooper, Jonathan C. Cohen, Shamil R. Sunyaev The American Journal of Human Genetics Volume 81, Issue 6, Pages 1298-1303 (December 2007) DOI: 10.1086/522497 Copyright © 2007 The American Society of Human Genetics Terms and Conditions

Figure 1 Dependence of HDL-C levels on the total number of HDL-lowering alleles of the four SNPs included in the model. The figure shows HDL-C levels rather than the logarithmic HDL-C levels used in the analysis. For illustration, we show the number of derived alleles without regression coefficients of the corresponding SNPs. A, Training set. B, Testing set. C, Validation set. The American Journal of Human Genetics 2007 81, 1298-1303DOI: (10.1086/522497) Copyright © 2007 The American Society of Human Genetics Terms and Conditions