Sulfonamides and Trimethoprim

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Sulfonamides and Trimethoprim Chapter 84 Sulfonamides and Trimethoprim

Sulfonamides and Trimethoprim Broad spectrum antibiotics Suppresses bacterial growth by inhibiting folic acid Urinary tract infections Adverse effects Hypersensitivity reactions—Stevens-Johnson syndrome Hematologic effects Kernicterus Crystalluria

Trimethoprim (Proloprim and Trimpex) Urinary tract infections Hematologic effects

Trimethoprim-Sulfamethoxazole Uses Uncomplicated urinary tract infection Pneumocystis carinii – GI infections Adverse effects Gastrointestinal Rash – Crystalluria