The efficacy of 12 weeks non-surgical treatment for patients not eligible for total knee replacement: a randomized controlled trial with 1-year follow-up 

Slides:



Advertisements
Similar presentations
Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.
Advertisements

Knee osteoarthritis radiographic progression and associations with pain and function prior to knee arthroplasty: a multicenter comparative cohort study 
Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis  C. Zeng, H. li, T. Yang, Z.-h. Deng, Y. Yang,
C. Fingleton, K. Smart, N. Moloney, B.M. Fullen, C. Doody 
NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial  R. Leighton, C. Åkermark,
Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis  C. Zeng, H. li, T. Yang, Z.-h. Deng, Y. Yang,
Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis  M.S. Corbett, S.J.C. Rice,
Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis  Z. Huang, J. Chen, J. Ma, B. Shen,
Short-term placebo response in trials of patients with symptomatic osteoarthritis: differences between hip and knee  S. Reiter-Niesert, M. Boers, J. Detert 
Efficacy of patient education and supervised exercise vs patient education alone in patients with hip osteoarthritis: a single blind randomized clinical.
Dr L. S. Kim, N. D. , Dr L. J. Axelrod, N. D. , Dr P. Howard, M. D
Efficacy and safety of naproxcinod in the treatment of patients with osteoarthritis of the knee: a 13-week prospective, randomized, multicenter study 
Cross-cultural adaptation and validation of the French version of the Knee injury and Osteoarthritis Outcome Score (KOOS) in knee osteoarthritis patients 
Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis – treatment effects of neuromuscular exercise.
Disability and quality of life of patients with knee or hip osteoarthritis in the primary care setting and factors associated with general practitioners'
Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee. 2: economic evaluation alongside a randomized.
Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study 
One year effectiveness of neuromuscular exercise compared with instruction in analgesic use on knee function in patients with early knee osteoarthritis:
The effect of instruction in analgesic use compared with neuromuscular exercise on knee-joint load in patients with knee osteoarthritis: a randomized,
Is a high tibial osteotomy (HTO) superior to non-surgical treatment in patients with varus malaligned medial knee osteoarthritis (OA)? A propensity matched.
Influence of flare design on symptomatic efficacy of non-steroidal anti-inflammatory drugs in osteoarthritis: a meta-analysis of randomized placebo-controlled.
Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized,
Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials  M. Fransen, S.
Development of a simplified Chinese version of the hip disability and osteoarthritis outcome score (HOOS): cross-cultural adaptation and psychometric.
Successful nonoperative management of chronic osteoarthritis pain of the knee: safety and efficacy of retreatment with intra-articular hyaluronans  Mark.
P.S. McCabe, N. Maricar, M.J. Parkes, D.T. Felson, T.W. O'Neill 
Cross-cultural adaptation and implementation of Good Life with osteoarthritis in Denmark (GLA:D™): group education and exercise for hip and knee osteoarthritis.
Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery – a.
Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial  R.W. Brouwer, M.D., T.M. van Raaij, M.D., J.A.N. Verhaar,
The effect of waiting time on health and quality of life outcomes and costs of medication in hip replacement patients: a randomized clinical trial  U.
Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: a randomized,
Knee cartilage assessment with MRI (dGEMRIC) and subjective knee function in ACL injured copers: a cohort study with a 20 year follow-up  P. Neuman, H.
Are bisphosphonates efficacious in knee osteoarthritis
Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial  L.L.
J. Avouac, M.D., L. Gossec, M.D., M. Dougados, M.D. 
Risk factors associated with reduced work productivity among people with chronic knee pain  M. Agaliotis, M. Fransen, L. Bridgett, L. Nairn, M. Votrubec,
J. Ranstam  Osteoarthritis and Cartilage 
Psychological factors and their relation to osteoarthritis pain
The combined efficacy of multimodal non-surgical treatment on pain and sensitization in patients with knee osteoarthritis not eligible for a total knee.
A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee 
Osteoarthritis year 2010 in review: non-pharmacologic therapy
Knee arthroscopic surgery is beneficial to middle-aged patients with meniscal symptoms: a prospective, randomised, single-blinded study  H. Gauffin, S.
Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis  Y. Laufer,
Efficacy and safety of duloxetine in Chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study  G.
Efficacy of low frequency pulsed subsensory threshold electrical stimulation vs placebo on pain and physical function in people with knee osteoarthritis:
Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing.
Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials  E.M. Bartels, V.N. Folmer, H. Bliddal,
Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a randomized controlled trial comparing two different.
Who should have a joint replacement? A plea for more ‘phronesis’
Knee Injury and Osteoarthritis Outcome Score (KOOS): systematic review and meta- analysis of measurement properties  N.J. Collins, C.A.C. Prinsen, R. Christensen,
Prevalence and changes in analgesic medication utilisation 1 year prior to total joint replacement in an older cohort of patients  M.C.S. Inacio, K. Cashman,
Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial  B.F. Riecke,
Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study.
A single center, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy and safety of intra-articular onabotulinumtoxina as.
A 2-year follow-up of a study to compare the efficacy of lateral wedged insoles with subtalar strapping and in-shoe lateral wedged insoles in patients.
I.C. Olsen, T.K. Kvien, T. Uhlig  Osteoarthritis and Cartilage 
Does pre-surgical central modulation of pain influence outcome after total knee replacement? A systematic review  I.A.C. Baert, E. Lluch, T. Mulder, J.
D.J. Hunter  Osteoarthritis and Cartilage 
Total knee replacement followed by a non-surgical treatment program reduce localized and spreading pain sensitization – A pre-defined ancillary analysis.
No additional benefit of shortwave diathermy over exercise program for knee osteoarthritis in peri-/post-menopausal women: an equivalence trial  M. Rattanachaiyanont,
Limited effects of exercises in people with hand osteoarthritis: results from a randomized controlled trial  N. Østerås, K.B. Hagen, M. Grotle, A.-L.
C. Fingleton, K. Smart, N. Moloney, B.M. Fullen, C. Doody 
Acute resistance exercise and pressure pain sensitivity in knee osteoarthritis: a randomised crossover trial  N.J. Burrows, J. Booth, D.L. Sturnieks,
Osteoarthritis year 2012 in review: biology
Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure  A.C. Lee, W.F. Harvey, X. Han, L.L. Price,
Efficacy of rehabilitation programs for improving muscle strength in people with hip or knee osteoarthritis: a systematic review with meta-analysis  A.
Patient education with or without manual therapy compared to a control group in patients with osteoarthritis of the hip. A proof-of-principle three-arm.
Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: a randomized controlled trial. 1: clinical.
The effect of eight weeks of exercise on knee adduction moment in early knee osteoarthritis – a pilot study  C.A. Thorstensson, Ph.D., M. Henriksson,
Effect of a 16 weeks weight loss program on osteoarthritis biomarkers in obese patients with knee osteoarthritis: a prospective cohort study  E.M. Bartels,
Presentation transcript:

The efficacy of 12 weeks non-surgical treatment for patients not eligible for total knee replacement: a randomized controlled trial with 1-year follow-up  S.T. Skou, S. Rasmussen, M.B. Laursen, M.S. Rathleff, L. Arendt-Nielsen, O. Simonsen, E.M. Roos  Osteoarthritis and Cartilage  Volume 23, Issue 9, Pages 1465-1475 (September 2015) DOI: 10.1016/j.joca.2015.04.021 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow of patients in the study. K–L score = Kellgren–Lawrence score; KOOS4 = The average score for the subscale scores for pain, symptoms, ADL and QOL from the KOOS, VAS. Osteoarthritis and Cartilage 2015 23, 1465-1475DOI: (10.1016/j.joca.2015.04.021) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean subscale scores at all time points for the KOOS subscales of pain (A), symptoms (B), ADL (C), sports and recreational activities (Sport/Rec; D), and QOL (E) for the groups randomized to either a 12-week non-surgical treatment program consisting of neuromuscular exercise, education, diet, insoles, and pain medication (the MEDIC group) or usual care (the usual care group). The error bars indicate 95% confidence intervals. Osteoarthritis and Cartilage 2015 23, 1465-1475DOI: (10.1016/j.joca.2015.04.021) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions