Tumor Evolution: A Problem of Histocompatibility

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Tumor Evolution: A Problem of Histocompatibility Natalie I. Vokes, Eliezer M. Van Allen Cell Volume 171, Issue 6, Pages 1252-1253 (November 2017) DOI: 10.1016/j.cell.2017.11.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Role of HLA-Mediated Antigen Presentation in Immune Detection and Elimination of Cancer (A) Mutated cancer proteins are presented as neoantigens via the HLA-containing MHC class I complex to CD8+ T cells, triggering destruction of the transformed cell in a process called immunoediting. (B and C) Mechanisms of loss-of-antigen presentation, leading to cancer cell survival either by incompatible binding between the transformed protein and the individual’s HLA (B) or by loss of HLA heterozygosity (C). Cell 2017 171, 1252-1253DOI: (10.1016/j.cell.2017.11.012) Copyright © 2017 Elsevier Inc. Terms and Conditions