Effect of recombinant human TNF–binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in.

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Effect of recombinant human TNF–binding protein-1 and GnRH antagonist on mRNA expression of inflammatory cytokines and adhesion and growth factors in endometrium and endometriosis tissues in baboons Cleophas M. Kyama, M.Sc., Lutgart Overbergh, Ph.D., Attila Mihalyi, Ph.D., Silvio Cuneo, M.D., M.Sc., Daniel Chai, B.V.M., Sophie Debrock, Ph.D., Jason M. Mwenda, Ph.D., Chantal Mathieu, M.D., Ph.D., Noreen P. Nugent, Thomas M. D'Hooghe, M.D., Ph.D. Fertility and Sterility Volume 89, Issue 5, Pages 1306-1313 (May 2008) DOI: 10.1016/j.fertnstert.2006.11.205 Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Endometriotic lesions. Drug effect on the gene expression of TNF-α (A), ICAM-1 (B), TGF-β (C), and MMP-1 (D) in endometriotic lesions from baboons with induced endometriosis. The TGF-β mRNA expression was significantly lower in endometriosis lesions from baboons treated with recombinant human TNF-binding protein-1 (rhTBP-1) when compared with those obtained in the placebo group. ∗P<.05. HPRT = hypoxanthine phosphoribosyl transferase. Fertility and Sterility 2008 89, 1306-1313DOI: (10.1016/j.fertnstert.2006.11.205) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Endometrium. Drug effect on the gene expression of TNF-α (A), ICAM-1 (B), TGF-β (C), and MMP-1 (D) in eutopic endometrium from baboons with induced endometriosis. Quantitative evaluation of mRNA expression levels for TNF-α, TGF-β, MMP-1, and ICAM-1 was comparable in endometrium from baboons treated with recombinant human TNF-binding protein-1 (rhTBP-1) or the group treated with antide when compared with the placebo group. HPRT = hypoxanthine phosphoribosyl transferase. Fertility and Sterility 2008 89, 1306-1313DOI: (10.1016/j.fertnstert.2006.11.205) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Few TNF-α–positive cells were detected in the stromal region of endometriotic lesions (A′ [antide] and C′ [PBS]) and in connective tissue (B′ [recombinant human TNF-binding protein-1 (rhBP-1)]) in both treated and control groups. No positive immunohistochemical staining for TNF-α was detected in the epithelial or glandular regions from the endometriosis lesions in both treated groups (A [antide] or B [recombinant human TNF-binding protein-1 (rhTBP-1)]) and control groups (C [PBS]). Fertility and Sterility 2008 89, 1306-1313DOI: (10.1016/j.fertnstert.2006.11.205) Copyright © 2008 American Society for Reproductive Medicine Terms and Conditions