Figure 3 Defects in the T cell receptor signalling pathway

Slides:

Advertisements

Similar presentations

Advances in Molecular Biology of Lung Disease

Advertisements

A: inhibition of the erbB2 receptor abolished the protective effects of NRG1 on cTnI and cTnT in NRVM. NRVM were treated with Dox-NRG1 (20 ng/ml) in the.

by Rogelio Zamilpa, and Merry L. Lindsey

SIGNAL TRANSDUCTION Signal Transduction Pathway Protein Modification Phosphorylation Cascade Protein Kinases.

Figure 4 Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations Figure 4 | Tissue infiltration and lymphadenopathy in patients with CTLA4.

Figure 3 Metabolism in homeostatic chondrocytes

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 4 Simplified T cell and antigen presenting

Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era Joon H. Uhm, MD, Alyx B. Porter,

Figure 1 Current treatments for PNETs

IRS-1: Auditing the effectiveness of mTOR inhibitors

Figure 5 Defects in the JAK–STAT signalling pathway

Leptin and insulin signalling pathways in the Arc.

Figure 1 mTOR pathway activation

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Figure 4 Possible combination therapies CDK4/6 inhibitors

Figure 2 Therapeutic targeting of the PI3K/AKT/mTOR pathway

Nat. Rev. Clin. Oncol. doi: /nrclinonc

Figure 7 Defects in apoptosis

The Akt-mTOR tango and its relevance to cancer

Figure 1 A schematic representation of the HER2 signalling pathway

Figure 2 Co-stimulatory receptors as immunomodulatory targets

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 Intracellular actions of metformin

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Urol. doi: /nrurol

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 3 Integrative signalling networks enable interactions

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

Figure 1 Therapeutic targeting of the B-cell receptor (BCR)

Personalizing Therapy for Colorectal Cancer

Figure 3 Physiological regulation of autophagy in the heart

Nat. Rev. Endocrinol. doi: /nrendo

BDNF and insulin signaling pathways activated by phytochemicals.

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 mTOR complex biology

In-vitro regulation of primordial follicle activation: challenges for fertility preservation strategies Michael J. Bertoldo, Kirsty A. Walters, William.

Nat. Rev. Rheumatol. doi: /nrrheum

Volume 29, Issue 3, Pages (March 2016)

The pathway signalling starts with the binding of insulin or growth factors to insulin receptors. The pathway signalling starts with the binding of insulin.

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Schematic view of Trk receptors signalling, showing the three major pathways involved in cell differentiation and survival. Schematic view of Trk receptors.

Figure 1 Research advances in osteoarthritis management

PTEN Enters the Nuclear Age

Figure 1 The insulin signalling pathway

Nat. Rev. Rheumatol. doi: /nrrheum

Nat. Rev. Urol. doi: /nrurol

IRS-1: Auditing the effectiveness of mTOR inhibitors

The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing Marieke Hylebos, MSc, Guy Van Camp, PhD, Jan P van.

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Transmission of pain by NGF

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 2 A model of TNFR–complex I signalling

Figure 1 The mTOR signalling pathway

NOTCH and PI3K-AKT Pathways Intertwined

AKT/PKB Signaling: Navigating Downstream

Signalling links in the liver: Knitting SOCS with fat and inflammation

p38 MAPK activation is required for phosphorylation of Akt at Ser473.

Simon Ekman, MD, PhD, Murry W. Wynes, PhD, Fred R. Hirsch, MD, PhD

Tailor Made Protein Synthesis for HSCs

The rudimentary human β-cell mitogenic signaling road map.

Dysregulation of the mTOR Pathway Secondary to Mutations or a Hostile Microenvironment Contributes to Cancer and Poor Wound Healing Richard A.F. Clark,

Receptor tyrosine kinase (RTK) responds to external stimuli including extracellular matrix components and chemokines and subsequently activates phosphoinositide.

Signaling pathways of galanin receptors.

Connections between insulin/insulin-like growth factor 1 signaling and metabolic pathways in tumor cells. Connections between insulin/insulin-like growth.

The Ribosome and TORC2: Collaborators for Cell Growth

Presentation transcript:

Figure 3 Defects in the T cell receptor signalling pathway Figure 3 | Defects in the T cell receptor signalling pathway. Constitutive activation of phosphatidylinositol 4,5-bisphosphate 3-kinase δ (PI3Kδ) by gain-of-function mutations leads to an increase in RACα serine/threonine-protein kinase (AKT) phosphorylation and ribosomal protein S6 kinase β1 (S6K1) signalling. Loss of the PI3K inhibitor PTEN likewise leads to increased PI3Kδ activity, causing lymphoproliferation, autoimmunity and antibody deficiency. mTOR, mechanistic target of rapamycin; PIP2, phosphatidylinositol 4,5-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; TCR, T cell receptor. Schmidt, R. E. et al. (2017) Autoimmunity and primary immunodeficiency: two sides of the same coin? Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.198