Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis:

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Presentation transcript:

Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA) R.F. Loeser, D.P. Beavers, A.C. Bay-Jensen, M.A. Karsdal, B.J. Nicklas, A. Guermazi, D.J. Hunter, S.P. Messier Osteoarthritis and Cartilage Volume 25, Issue 11, Pages 1822-1828 (November 2017) DOI: 10.1016/j.joca.2017.07.015 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Effects of dietary weight loss and exercise interventions on biochemical markers of type I (C1M) and type III (C3M) collagen degradation. Serum samples from baseline, 6 month and 12 month blood collections were assayed for the indicated biochemical markers. The data (expressed as ng/ml) was log transformed and adjusted for baseline values and baseline BMI and gender. Mixed models were used to assess treatment group means and pairwise differences. Osteoarthritis and Cartilage 2017 25, 1822-1828DOI: (10.1016/j.joca.2017.07.015) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Effects of dietary weight loss and exercise interventions on biochemical markers of CRP (CRPM) and type II collagen (C2M) degradation. Serum samples from baseline, 6 month and 12 month blood collections were assayed for the indicated biochemical markers. The data (expressed as ng/ml) was log transformed and adjusted for baseline values and baseline BMI and gender. Mixed models were used to assess treatment group means and pairwise differences. Osteoarthritis and Cartilage 2017 25, 1822-1828DOI: (10.1016/j.joca.2017.07.015) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions