Toll-like Receptors Keep Antigen Sorting on the Right Track

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Presentation transcript:

Toll-like Receptors Keep Antigen Sorting on the Right Track Yvette van Kooyk, Teunis B.H. Geijtenbeek Immunity Volume 25, Issue 4, Pages 525-527 (October 2006) DOI: 10.1016/j.immuni.2006.09.006 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 TLR11 Recognition Regulates Antigen Presentation of Profilin Profilin interacts with TLR11, inducing the MyD88-signaling pathway. This results in selective uptake and efficient antigen processing and presentation in MHC Class II complexes. Simultaneously, MyD88 activation induces cytokine secretion and upregulation of costimulatory molecules, ensuring efficient immune activation by dendritic cells. Self antigens end up in different antigen-processing compartments as a result of a lack of TLR activation. Immunity 2006 25, 525-527DOI: (10.1016/j.immuni.2006.09.006) Copyright © 2006 Elsevier Inc. Terms and Conditions