Local control and overall survival after frameless radiosurgery: A single center experience Angelika Bilger, Florian Frenzel, Oliver Oehlke, Rolf Wiehle,

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Local control and overall survival after frameless radiosurgery: A single center experience Angelika Bilger, Florian Frenzel, Oliver Oehlke, Rolf Wiehle, Dusan Milanovic, Vesna Prokic, Carsten Nieder, Anca-Ligia Grosu Clinical and Translational Radiation Oncology Volume 7, Pages 55-61 (December 2017) DOI: 10.1016/j.ctro.2017.09.007 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 BrainLAB mask for patient positioning. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Competing Risks: Patients have a higher risk to die than to develop local recurrence. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 LC, Local control for 69 metastases treated with SRS (for 8 metastases no imaging follow-up was available.) The dash lines represent 95% confidence intervals. Tick marks represent censoring times/events. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 A. Progression-free intracranial survival for 41 patients treated with SRS (considering the first treated metastasis, seven patients had no imaging follow-up). The dash lines represent 95% confidence intervals. Tick marks represent censoring times/events. B Progression-free intracranial survival for all 48 patients treated with SRS (Interval censored). The dash lines represent 95% confidence intervals. Tick marks represent censoring times/events. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions

Fig. 5 OS, Overall survival in 48 patients treated with frameless SRS. The dash lines represent 95% confidence intervals. Tick marks represent censoring times/events. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions

Fig. 6 One patient treated by SRS, left: MRI before treatment, large metastasis with edema, the patient had a motoric weakness, right: MRI after treatment, there is only a small residuum of the metastasis left, the patient‘s weakness was much better, middle: conformal SRS treatment plan. Clinical and Translational Radiation Oncology 2017 7, 55-61DOI: (10.1016/j.ctro.2017.09.007) Copyright © 2017 The Authors Terms and Conditions