Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non– small cell lung cancer: A heterogeneous disease Chung-Ping Hsu, MD,

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Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non– small cell lung cancer: A heterogeneous disease Chung-Ping Hsu, MD, Jiun-Yi Hsia, MD, Gee-Chen Chang, MD, Cheng-Yen Chuang, MD, Sen-Ei Shai, MD, Shyh-Sheng Yang, MD, Ming-Ching Lee, MD, Po-Cheung Kwan, MD The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 2, Pages 426-433 (August 2009) DOI: 10.1016/j.jtcvs.2008.12.035 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Overall survival times of 57 patients with pT1 N0 M0 (stage IA) and 272 patients with pT2 N0 M0 (stage IB) non–small cell lung cancer after resection. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Survival analysis according to the types of resection. A, Survival curves for P (pneumonectomy), L (lobectomy), Bi-L (bilobectomy or lobectomy), W (wedge resection), and S (segmentectomy). B, Survival curves according to standard resections and limited resections. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Survival analysis according to tumor types. A, Survival curves for squamous cell carcinomas, adenocarcinomas, and other cell types. B, Survival curves according to the presence of BAC (bronchioloalveolar carcinoma) patterns. Adenocarcinoma+BAC, Adenocarcinoma with focal BAC component; BAC, pure bronchioloalveolar carcinoma. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Survival analysis according to cell differentiation. Well-differentiated (W) tumors had 5-year and 10-year survivals of 84.4% and 67.5%, respectively. M, Moderately differentiated; P, poorly differentiated. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Survival analysis according to tumor size. Patients with tumors less than 2 cm and 3 cm in diameter both had better long-term survivals than did their counterparts. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 6 A, Survival analysis according to the depth of visceral invasion in all groups. B, After exclusion of P0 group, patients with tumors of 3 cm or less in diameter had better long-term survivals than did their counterparts. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 7 Survival analysis according to the extent of lymphadenectomy. Patients who received a more extensive lymphadenectomy (A, retrieved nodes >14; B, D2 dissection) also had a better outcome. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 8 Survival analysis according to the presence of angiolymphatic (AL) invasion. Patients who had tumors with positive microscopic angiolymphatic invasion had a poorer prognosis. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 426-433DOI: (10.1016/j.jtcvs.2008.12.035) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions