Presentation is loading. Please wait.

Presentation is loading. Please wait.

Tumor histology predicts mediastinal nodal status and may be used to guide limited lymphadenectomy in patients with clinical stage I non–small cell lung.

Published byHannah Paul Modified over 5 years ago

Similar presentations

Presentation on theme: "Tumor histology predicts mediastinal nodal status and may be used to guide limited lymphadenectomy in patients with clinical stage I non–small cell lung."— Presentation transcript:

1 Tumor histology predicts mediastinal nodal status and may be used to guide limited lymphadenectomy in patients with clinical stage I non–small cell lung cancer  Xinghua Cheng, MD, PhD, Difan Zheng, MD, Yuan Li, MD, Hang Li, MD, Yihua Sun, MD, Jiaqing Xiang, MD, Haiquan Chen, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 155, Issue 6, Pages e2 (June 2018) DOI: /j.jtcvs Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Consort diagram of patient selection. NSCLC, Non–small cell lung cancer. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Mediastinal lymph node metastasis in different histologic subtypes of clinical stage I NSCLC. The percentages of pN2 are presented at different tumor sizes for patients with (A) AIS/MIA/LPA, (B) APA/PPA/IMA, (C) MPA/SPA, (D) SCC, and (E) other NSCLC. F, Overall pN2 rate in clinical stage I NSCLC. AIS, Adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; LPA, lepidic pattern–predominant adenocarcinoma; APA, acinar pattern–predominant adenocarcinoma PPA, papillary pattern–predominant adenocarcinoma; IMA, invasive mucinous adenocarcinoma; MPA, micropapillary pattern–predominant adenocarcinoma; SPA, solid pattern–predominant adenocarcinoma; SCC, squamous cell carcinoma. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Survival of patients with LPA. The 5-year (A) RFS and (B) OS were not different between patients with LPA after LMLD (n = 82) and those after CMLD (n = 139). RFS, Recurrence-free survival; LMLD, limited mediastinal lymphadenectomy; CMLD, complete mediastinal lymph node dissection; OS, overall survival. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

5 Figure E1 Proportions of tumors ≤2 cm in patients with different histologic subtypes of clinical stage I NSCLC. The percentages of tumor ≤2 cm are presented for patients with AIS/MIA/LPA, APA/PPA/IMA, MPA/SPA, SCC, and other NSCLC. AIS, Adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; LPA, lepidic pattern–predominant adenocarcinoma; APA, acinar pattern–predominant adenocarcinoma PPA, papillary pattern–predominant adenocarcinoma; IMA, invasive mucinous adenocarcinoma; MPA, micropapillary pattern–predominant adenocarcinoma; SPA, solid pattern–predominant adenocarcinoma; SCC, squamous cell carcinoma. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

6 Figure E2 Survivals of patients with clinical stage I NSCLC. The (A) RFS and (B) OS were significantly different among patients with clinical stage I NSCLC who had pN0 (n = 1122), pN1 (n = 106), and pN2 (n = 202) metastasis. The 5-year RFS and OS of patients with lepidic adenocarcinoma were significantly better than other pN0 NSCLC (99.3% vs 77.1%, P < .001 and 99.3% vs 91.5%, P = .001, respectively). RFS, Recurrence-free survival; OS, overall survival. The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

7 Selection of patients with low risk of pN2 by frozen section diagnosis in cStage I NSCLC.
The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

8 Video 1 Complete mediastinal lymph node dissection via video-assisted thoracoscopic surgery or open thoracotomy.Video available at: The Journal of Thoracic and Cardiovascular Surgery  , e2DOI: ( /j.jtcvs ) Copyright © 2018 The American Association for Thoracic Surgery Terms and Conditions

Download ppt "Tumor histology predicts mediastinal nodal status and may be used to guide limited lymphadenectomy in patients with clinical stage I non–small cell lung."

Similar presentations

The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.

The prognostic importance of the number of involved lymph nodes in esophageal cancer: Implications for revisions of the American Joint Committee on Cancer.
Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma  Kazuya Takamochi, MD, Shiaki Oh, MD,

Prognostic impacts of EGFR mutation status and subtype in patients with surgically resected lung adenocarcinoma  Kazuya Takamochi, MD, Shiaki Oh, MD,
The Correlation of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS)

The Correlation of the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS)
Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,

Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies  Sai-Hong Ignatius Ou, MD,
Michael F. Nentwich, MD, Benjamin A. Bohn, MD, Faik G

Michael F. Nentwich, MD, Benjamin A. Bohn, MD, Faik G
Synchronous multiple primary lung cancer: An increasing clinical occurrence requiring multidisciplinary management  Delphine Trousse, MD, Fabrice Barlesi,

Synchronous multiple primary lung cancer: An increasing clinical occurrence requiring multidisciplinary management  Delphine Trousse, MD, Fabrice Barlesi,
Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma  Arianna.

Definitive chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by surgery for stage II to III esophageal squamous cell carcinoma  Arianna.
Michael Y. Chang, MD, MPH, Steven J. Mentzer, MD, Yolonda L

Michael Y. Chang, MD, MPH, Steven J. Mentzer, MD, Yolonda L
Local recurrence after surgery for non–small cell lung cancer: A recursive partitioning analysis of multi-institutional data  Chris R. Kelsey, MD, Kristin.

Local recurrence after surgery for non–small cell lung cancer: A recursive partitioning analysis of multi-institutional data  Chris R. Kelsey, MD, Kristin.
Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non– small cell lung cancer: A heterogeneous disease  Chung-Ping Hsu, MD,

Surgical–pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non– small cell lung cancer: A heterogeneous disease  Chung-Ping Hsu, MD,
Impact of Solid Minor Histologic Subtype in Postsurgical Prognosis of Stage I Lung Adenocarcinoma  Tianxiang Chen, MD, PhD, Jizhuang Luo, MD, Haiyong.

Impact of Solid Minor Histologic Subtype in Postsurgical Prognosis of Stage I Lung Adenocarcinoma  Tianxiang Chen, MD, PhD, Jizhuang Luo, MD, Haiyong.
Surgical quality of wedge resection affects overall survival in patients with early stage non–small cell lung cancer  Gaurav S. Ajmani, MHS, Chi-Hsiung.

Surgical quality of wedge resection affects overall survival in patients with early stage non–small cell lung cancer  Gaurav S. Ajmani, MHS, Chi-Hsiung.
Negative Thyroid Transcription Factor 1 Expression Defines an Unfavorable Subgroup of Lung Adenocarcinomas  Yiliang Zhang, MD, Rui Wang, MD, PhD, Yuan.

Negative Thyroid Transcription Factor 1 Expression Defines an Unfavorable Subgroup of Lung Adenocarcinomas  Yiliang Zhang, MD, Rui Wang, MD, PhD, Yuan.
Does the method of radiologic surveillance affect survival after resection of stage I non– small cell lung cancer?  Traves D. Crabtree, MD, Varun Puri,

Does the method of radiologic surveillance affect survival after resection of stage I non– small cell lung cancer?  Traves D. Crabtree, MD, Varun Puri,
Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than.

Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than.
Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 

Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non–small cell lung cancer 
Paul J. Scheel, BS, Traves D. Crabtree, MD, Jennifer M

Paul J. Scheel, BS, Traves D. Crabtree, MD, Jennifer M
Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system  Shamus R.

Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system  Shamus R.
Yih-Leong Chang, MD, Chen-Tu Wu, MD, Yung-Chie Lee, MD, PhD 

Yih-Leong Chang, MD, Chen-Tu Wu, MD, Yung-Chie Lee, MD, PhD 
Esophageal submucosa: The watershed for esophageal cancer

Esophageal submucosa: The watershed for esophageal cancer

Similar presentations

Ads by Google