Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency by Ronald.

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Presentation transcript:

Full hematopoietic engraftment after allogeneic bone marrow transplantation without cytoreduction in a child with severe combined immunodeficiency by Ronald J. Rubocki, Jennifer R. Parsa, Michael S. Hershfield, Warren G. Sanger, Samuel J. Pirruccello, Ines Santisteban, Bruce G. Gordon, Sarah E. Strandjord, Phyllis I. Warkentin, and Peter F. Coccia Blood Volume 97(3):809-811 February 1, 2001 ©2001 by American Society of Hematology

Graphic representation of hematologic parameters and engraftment status at selected times after bone marrow transplantation.Blood components (absolute lymphocyte count [ALC], absolute neutrophil count [ANC], platelets) and hemoglobin values are shown in the... Graphic representation of hematologic parameters and engraftment status at selected times after bone marrow transplantation.Blood components (absolute lymphocyte count [ALC], absolute neutrophil count [ANC], platelets) and hemoglobin values are shown in the lower panel. Percentage donor cells analyzed by cytogenetics in the recipient after transplantation are shown in the top panel. A specific 1qh+ polymorphism was detected in the recipient before BMT. At 1 and 3 months after BMT, analysis of PHA-stimulated PBLs demonstrated mixed chimerism. Full donor engraftment was found at 6 months, and all subsequent findings of PBLs and BM (at 1 and 8 years) have remained 100% of donor origin. Ronald J. Rubocki et al. Blood 2001;97:809-811 ©2001 by American Society of Hematology