Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory.

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Presentation transcript:

Surgical reconstruction of ruptured anterior cruciate ligament prolongs trauma-induced increase of inflammatory cytokines in synovial fluid: an exploratory analysis in the KANON trial S. Larsson, A. Struglics, L.S. Lohmander, R. Frobell Osteoarthritis and Cartilage Volume 25, Issue 9, Pages 1443-1451 (September 2017) DOI: 10.1016/j.joca.2017.05.009 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Number of subjects and cumulative number of surgeries on the index knee of the subjects ordered by time after injury of the intervention grouped (A) as randomized, and (B) as treated. Black thick horizontal lines; total number of subjects in the groups. Red thick lines, cumulative number of ACL reconstruction (ACLR) surgeries. Black thin lines, cumulative number of surgeries for other reasons than ACLR (non-ACLR surgeries). Vertical gray lines, mean time after injury of visits from visit 1 (baseline; BL) to visit 6 (5 years). Osteoarthritis and Cartilage 2017 25, 1443-1451DOI: (10.1016/j.joca.2017.05.009) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean log biomarker concentrations in groups as randomized (full analysis set) in synovial fluid (sf), serum (s) and urine (u) at six visits over 5 years. Circles (early ACL reconstruction), triangles (optional delayed ACL reconstruction) and error bars, means with 95% confidence intervals (CI) of injured subjects at each visit. Asterisk, statistically significant difference in biomarker concentrations at that visit between groups as randomized. Dashed line and dark gray area, mean and 95% CI of the knee-healthy reference group. (A) Inflammatory cytokines in synovial fluid. (B) ARGS-aggrecan in synovial fluid and serum. (C) C-terminal crosslinking telopeptide of type II collagen (CTX-II) and N-terminal crosslinking telopeptide of type I collagen (NTX-I) in urine with compensation for creatinine. ACLR, ACL reconstruction. Numerical data is reported in Supplementary Table 1. Osteoarthritis and Cartilage 2017 25, 1443-1451DOI: (10.1016/j.joca.2017.05.009) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean log biomarker concentrations in groups as treated in synovial fluid (sf), serum (s) and urine (u) at six visits over 5 years. Empty circles (early ACL reconstruction), filled circles (rehabilitation alone), triangles (delayed ACL reconstruction) and error bars, means with 95% confidence intervals (CI) of injured subjects at each visit. Statistically significant difference in biomarker concentrations between groups are indicated for comparisons at each visit by X (early ACL reconstruction vs rehabilitation alone), and + (delayed ACL reconstruction vs rehabilitation alone). Dashed line and dark gray area, mean and 95% CI of the knee-healthy reference group. (A) Inflammatory cytokines in synovial fluid. (B) ARGS-aggrecan in synovial fluid and serum. (C) C-terminal crosslinking telopeptide of type II collagen (CTX-II) and N-terminal crosslinking telopeptide of type I collagen (NTX-I) in urine with compensation for creatinine. ACLR, ACL reconstruction. Numerical data is reported in Supplementary Table 2. Osteoarthritis and Cartilage 2017 25, 1443-1451DOI: (10.1016/j.joca.2017.05.009) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions