Cyberinfrastructure for the Life Sciences (and beyond) PI: Parker Antin, University of Arizona Professor of Cellular and Molecular Medicine Associate Dean for Research of the College of Agriculture and Life Sciences Eric Lyons Nirav Merchant Matthew Vaughn Doreen Ware David Micklos Ann Stapleton Karen Cone, Program Director National Science Foundation September 2016

CyVerse is a Cyberinfrastructure Vision: Transforming science through data-driven discovery Mission: To design, develop, deploy, and expand a national cyberinfrastructure for life science research, and to train scientists in its use 2

National Science Foundation Biological Sciences Directorate CyVerse is funded by National Science Foundation Biological Sciences Directorate Division of Biological Infrastructure $100 Million, 10-year investment CyVerse resources are: Freely available to the community Intended to spur national and international collaboration for research and education DBI-0735191 and DBI-1265383 3

The Evolution of CyVerse From plant science, to life science, and beyond… iPlant 2008 Empowering a New Plant Biology iPlant 2013 Cyberinfrastructure for Life Science CyVerse 2016 Transforming Science Through Data-Driven Discovery 4

CyVerse supports all domains of life science Plant / Microbial Animal Biomedical Ecological/Climate …by providing powerful computational infrastructure to handle huge datasets and complex analyses Platforms, tools, datasets Storage and compute Training and support 5

CyVerse Supports Users at All Levels User perspectives and potential applications Bench Scientist Bioinformatician Core Facilities Welch et al. 2013 6

CyVerse Cyberinfrastructure: Architecture and Products Federated Storage National CI Virtualization Job Scheduling Single Sign-on Science platforms Domain-specific services Established software and CI Hardware resources Ease of Use 7

Products Overview 8 Atmosphere User-provisioned, highly configurable cloud computing environment tailored for life sciences Discovery Environment Web-accessible analysis workbench and gateway to national HPC infrastructure (XSEDE) Bisque Software for managing, analyzing and visualizing high throughput imaging data Data Store Scalable data storage for managing and sharing data across CyVerse’s CI and external data resources Science APIs Automation interfaces to connect data and computation for rapid integration with external resources. Also used as a graduate teaching platform. DNA Subway Classroom-friendly bioinformatics teaching platform Powered by CyVerse Third-party applications built on CyVerse’s foundational services and infrastructure 8

How CyVerse is Being Used Build new systems -- Powered by CyVerse components, but managed by the builders Consume specific components (a la carte, Data Store, Atmosphere, Bisque) Directly use applications (Discovery Environment) Custom design appliances (Atmosphere) Publish findings and data Create learning materials and courses Advocate use 9

CyVerse: Reference CI Model Transforming Research in All Disciplines Physical Sciences Plant Sciences Science platforms and Domain-specific services Animal Sciences Increased disciplinary emphasis Increased interdisciplinary sharing Established software and CI Federated Storage Job Scheduling Single Sign-on National CI Virtualization Hardware resources 10

CyVerse: Hub of a Growing CI Ecosystem Plant genomics, phenomics, and systems biology Bovine genomics Biological Sciences Marine virus metagenomics Immunology research data Earthquake, wind and water hazards modeling Physical Sciences Astronomy data curation and management 11

Summary CyVerse is a data-to-discovery cyberinfrastructre platform that is transforming life science research CyVerse is a reference model for cyberinfrastructure Extensible to other disciplines Scalable for big data analysis www.cyverse.org 12