Knee osteoarthritis patients with severe nocturnal pain have altered proximal tibial subchondral bone mineral density W.D. Burnett, S.A. Kontulainen,

Slides:

Advertisements

Similar presentations

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Advertisements

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

The relationships between bone mineral density in the spine, hip, distal femur and proximal tibia and medial minimum joint space width in the knees of.

Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis S.K. Boyd, Ph.D., R. Müller, Ph.D.,

Tribological and material properties for cartilage of and throughout the bovine stifle: support for the altered joint kinematics hypothesis of osteoarthritis

An Investigation of High Density Mineralised Protrusions in Human Cadaveric Knees by MRI and Microtomography N.P. Thomas, N. Jeffery, R. van 't Hof,

The groove model of osteoarthritis applied to the ovine fetlock joint

S. Seah, D. Wheaton, L. Li, J. P. Dyke, C. Talmo, W. F. Harvey, D. J

Biomechanical and cellular segmental characterization of human meniscus: building the basis for Tissue Engineering therapies H. Pereira, S.G. Caridade,

Calcification of human articular knee cartilage is primarily an effect of aging rather than osteoarthritis H. Mitsuyama, M.D., Ph.D., R.M. Healey, B.S.,

Whole-body vibration of mice induces articular cartilage degeneration with minimal changes in subchondral bone M.R. McCann, C. Yeung, M.A. Pest, A. Ratneswaran,

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice S. Hashimoto, M.F. Rai, K.L.

Patient-specific chondrolabral contact mechanics in patients with acetabular dysplasia following treatment with peri-acetabular osteotomy C.L. Abraham,

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase- induced model of osteoarthritis S.M. Botter, M.Sc., G.J.V.M. van.

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

C. R. Henak, C. L. Abraham, A. E. Anderson, S. A. Maas, B. J. Ellis, C

Knee joint subchondral bone structure alterations in active athletes: a cross-sectional case–control study F.W. Roemer, M. Jarraya, J. Niu, J. Duryea,

Knee osteoarthritis in community-dwelling older adults: are there characteristic patterns of pain location? L.R.J. Wood, Ph.D., M.C.S.P., G. Peat, Ph.D.,

The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial D.J. Hunter, L.S. Lohmander, J. Makovey, J.

Cancellous bone differences between knees with early, definite and advanced joint space loss; a comparative quantitative macroradiographic study Elizabeth.

Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight I.G. Otterness, Ph.D., F. Eckstein, M.D.

Sensitivity to Change of 3D Meniscal Measures in Rapidly Progressing Knee Osteoarthritis and Association With Radiographic Joint Space Width Loss M.

K.D. Allen, C.J. Coffman, Y.M. Golightly, K.M. Stechuchak, F.J. Keefe

Predictive and concurrent validity of cartilage thickness change as a marker of knee osteoarthritis progression: data from the Osteoarthritis Initiative

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Structural correlates of pain in joints with osteoarthritis

S. Reichenbach, M. D. , A. Guermazi, M. D. , J. Niu, M. B. B. S. , D

Change in bone area does not correlate with cartilage loss over 12 months in individuals with knee OA: Data from the osteoarthritis initiative M.A. Bowes,

Osteoarthritis and Cartilage

Protective effects of a cathepsin K inhibitor, SB , in the canine partial medial meniscectomy model of osteoarthritis J.R. Connor, C. LePage, B.A.

Quantification of differences in bone texture from plain radiographs in knees with and without osteoarthritis J. Hirvasniemi, J. Thevenot, V. Immonen,

Differences in trabecular bone texture between knees with and without radiographic osteoarthritis detected by fractal methods P. Podsiadlo, Ph.D., L.

A.C. Dang, M.D., A.P. Warren, M.D., H.T. Kim, M.D., Ph.D.

Pain has a stronger association with thigh muscle strength than the radiographic stage of knee osteoarthritis - data from the Osteoarthritis Initiative

Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis

Risk factors associated with reduced work productivity among people with chronic knee pain M. Agaliotis, M. Fransen, L. Bridgett, L. Nairn, M. Votrubec,

J. Ranstam Osteoarthritis and Cartilage

Subregional femorotibial cartilage morphology in women – comparison between healthy controls and participants with different grades of radiographic knee.

Psychological factors and their relation to osteoarthritis pain

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

Quantitative regional and sub-regional analysis of femoral and tibial subchondral bone mineral density (sBMD) using computed tomography (CT): comparison.

A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee

The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores N.L.A. Fell, B.M. Lawless,

Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis B.C.

M.Y. Chan, J.R. Center, J.A. Eisman, T.V. Nguyen

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study M.E. Duclos, O. Roualdes, R. Cararo, J.C. Rousseau,

Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary.

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

Tibial cancellous bone changes in patients with knee osteoarthritis

G. H. Lo, M. D. , M. Sc. , J. Niu, M. D. , D. Sc. , C. E. McLennan, M

A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia D. Dore, BBiotech.(Hons.), C. Ding, M.D., G.

Region of interest analysis: by selecting regions with denuded areas can we detect greater amounts of change? D.J. Hunter, L. Li, Y.Q. Zhang, S. Totterman,

D.J. Hunter Osteoarthritis and Cartilage

Changes to the articular cartilage thickness profile of the tibia following anterior cruciate ligament injury E.C. Argentieri, D.R. Sturnick, M.J. DeSarno,

Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the Knee Clinical Assessment Study and the Osteoarthritis.

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus C.Y. Wen, Y. Chen, H.L. Tang, C.H. Yan,

Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary.

Acute resistance exercise and pressure pain sensitivity in knee osteoarthritis: a randomised crossover trial N.J. Burrows, J. Booth, D.L. Sturnieks,

Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years J. Carnes, O.

Trajectory of cartilage loss within 4 years of knee replacement – a nested case–control study from the Osteoarthritis Initiative F. Eckstein, R.M. Boudreau,

L.A. Deveza, L. Melo, T.P. Yamato, K. Mills, V. Ravi, D.J. Hunter

M. Hudelmaier, W. Wirth Osteoarthritis and Cartilage

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

I. Gurkan, A. Ranganathan, X. Yang, W. E. Horton, M. Todman, J

Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles J. Malda,

Association between bone marrow lesions detected by magnetic resonance imaging and knee pain in community residents in Korea I.J. Kim, D.H. Kim, J.Y.

General Information Osteoarthritis and Cartilage

Presentation transcript:

Knee osteoarthritis patients with severe nocturnal pain have altered proximal tibial subchondral bone mineral density W.D. Burnett, S.A. Kontulainen, C.E. McLennan, D. Hazel, C. Talmo, D.J. Hunter, D.R. Wilson, J.D. Johnston Osteoarthritis and Cartilage Volume 23, Issue 9, Pages 1483-1490 (September 2015) DOI: 10.1016/j.joca.2015.04.012 Copyright © 2015 Terms and Conditions

Fig. 1 Representative topographical colormaps of proximal tibial BMD at depths of 0–2.5 mm (top row) and 2.5–5 mm (bottom row) in one participant reporting ‘no pain’, ‘moderate pain’, and ‘severe pain’ at night in bed. Regional analysis includes average BMD of the lateral and medial plateaus, and average maximum BMD of a 10 mm diameter focal spot (shown in upper left-hand image) localized on the maximum value of each lateral and medial plateau. Osteoarthritis and Cartilage 2015 23, 1483-1490DOI: (10.1016/j.joca.2015.04.012) Copyright © 2015 Terms and Conditions

Fig. 2 Adjusted mean regional BMD of each group (‘no pain’, ‘moderate pain’, and ‘severe pain’) at depths of 0–2.5 mm, 2.5–5 mm, and 5–10 mm from the subchondral surface. Statistically significant differences (P < 0.05) between groups are noted with brackets. Error bars represent 95% confidence intervals. Osteoarthritis and Cartilage 2015 23, 1483-1490DOI: (10.1016/j.joca.2015.04.012) Copyright © 2015 Terms and Conditions