Gerard Karsenty, Michael D. Gershon Gastroenterology

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The Importance of the Gastrointestinal Tract in the Control of Bone Mass Accrual Gerard Karsenty, Michael D. Gershon Gastroenterology Volume 141, Issue 2, Pages 439-442 (August 2011) DOI: 10.1053/j.gastro.2011.06.011 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Gut-derived serotonin regulates bone mass accrual. LDL receptor related protein 5 (Lrp5) favors bone formation by inhibiting tryptophan hydroxylase 1 (Tph1) expression in enterochromaffin cells of the duodenum. Gut-derived serotonin, following its binding to Htr1B, inhibits Creb expression, which results in a decrease in Cyclin expression and osteoblast proliferation. Gastroenterology 2011 141, 439-442DOI: (10.1053/j.gastro.2011.06.011) Copyright © 2011 AGA Institute Terms and Conditions