Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant.

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Presentation transcript:

Impact of donor type on outcome of bone marrow transplantation for Wiskott-Aldrich syndrome: collaborative study of the International Bone Marrow Transplant Registry and the National Marrow Donor Program by Alexandra H. Filipovich, Judy V. Stone, Sandra C. Tomany, Michele Ireland, Craig Kollman, Corey J. Pelz, James T. Casper, Morton J. Cowan, John R. Edwards, Anders Fasth, Robert Peter Gale, Anne Junker, Naynesh R. Kamani, Brett J. Loechelt, Daniel W. Pietryga, Olle Ringdén, Marcus Vowels, Janet Hegland, Aronica V. Williams, John P. Klein, Kathleen A. Sobocinski, Philip A. Rowlings, and Mary M. Horowitz Blood Volume 97(6):1598-1603 March 15, 2001 ©2001 by American Society of Hematology

Probabilities of survival for 170 patients receiving bone marrow transplants for Wiskott-Aldrich syndrome by donor type and age.There was not a significant difference in the risk of mortality after HLA-matched sibling transplants and after unrelated donor t... Probabilities of survival for 170 patients receiving bone marrow transplants for Wiskott-Aldrich syndrome by donor type and age.There was not a significant difference in the risk of mortality after HLA-matched sibling transplants and after unrelated donor transplants in children younger than 5 years. Significantly worse survival was associated with use of related donors other than HLA-identical siblings, regardless of recipient age, and with use of unrelated donors in patients over 5 years of age. Alexandra H. Filipovich et al. Blood 2001;97:1598-1603 ©2001 by American Society of Hematology