Gene expression analysis of a new source of human oocytes and embryos for research and human embryonic stem cell derivation Sharon F. Sneddon, Ph.D.,

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Gene expression analysis of a new source of human oocytes and embryos for research and human embryonic stem cell derivation Sharon F. Sneddon, Ph.D., Paul A. DeSousa, Ph.D., Ruth E. Arnesen, M.Phil., Brian A. Lieberman, M.B.B.Ch., Susan J. Kimber, Ph.D., Daniel R. Brison, Ph.D. Fertility and Sterility Volume 95, Issue 4, Pages 1410-1415 (March 2011) DOI: 10.1016/j.fertnstert.2010.08.050 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Expression of cell fate genes in single oocytes and preimplantation human embryos from pronucleate to blastocyst (n = 3 per stage). Open bars indicate control (unactivated) oocytes and embryos, and black bars indicate chemically activated oocytes and embryos. Statistical analysis revealed no significant difference between control and activated groups. Fertility and Sterility 2011 95, 1410-1415DOI: (10.1016/j.fertnstert.2010.08.050) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Diagram indicating the stage-specific or constitutive expression of genes detected in this study and the role they play in cell fate specification in the blastocyst. Based on Kimber et al. (35). Fertility and Sterility 2011 95, 1410-1415DOI: (10.1016/j.fertnstert.2010.08.050) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions