Keith Worsley 1951-2009
Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, Regression and Group Analysis Pipeline with Statistical Parametric Mapping SPM John Ashburner Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK.
Statistical Parametric Mapping (SPM) Image time-series Kernel Design matrix Statistical parametric map (SPM) Realignment Smoothing General linear model Gaussian field theory Statistical inference Normalisation p <0.05 Template Parameter estimates
SPM Interface and Batch mode
Pre-processing Overview Statistics or whatever fMRI time-series Template Anatomical MRI Smoothed Estimate Spatial Norm Motion Correct Smooth Coregister Spatially normalised Deformation
Batch Pre-processing
DARTEL Normalisation Simultaneous registration of GM to GM and WM to WM Template is an average shaped brain. Less bias in subsequent analysis. Iteratively created mean using DARTEL algorithm. Generative model of data. Multinomial noise model. Grey matter average of 471 subjects White matter average of 471 subjects
DARTEL Batch
Specify the Design for GLM Design matrix = + y X Parameter estimation
Batch 1st Level Analysis (Specify Design, Estimate, Result)
Group Analysis Of Summary Statistics First level Second level Data Design Matrix Contrast Images SPM(t) One-sample t-test @ 2nd level
2nd Level Analysis (Group Analysis)
SPM Resource http://www.fil.ion.ucl.ac.uk/spm “Human Brain Function” & “Statistical Parametric” Mapping books peer reviewed literature SPM email discussion list algorithm descriptions, code annotations, pseudo-code & SPM5/8 Manual