Progenitor Cells of Interstitial Cells of Cajal: On the Road to Tissue Repair  Jan D. Huizinga, Elizabeth J. White  Gastroenterology  Volume 134, Issue 4, Pages 1252-1254 (April 2008) DOI: 10.1053/j.gastro.2008.02.074 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Possible pathways for maintenance, repair, and regeneration of interstitial cells of Cajal (ICC), focused on pacemaker ICC associated with Auerbach’s (myenteric) plexus. All pathways are still at the stage of hypotheses. Immunohistochemical characteristics are largely based Lorincz et al.17 InsR, insulin receptor; IGF-IR, insulin-like growth factor I receptor. The “fibroblast-like cells” or fibroblast-like ICC27,28 may also have myoid features and may be Kit positive (see Torihashi et al30) and/or may have gap junction contact with smooth muscle cells and each other.27,28 Capability to generate pacemaker electrical slow wave activity is indicated by (). Gastroenterology 2008 134, 1252-1254DOI: (10.1053/j.gastro.2008.02.074) Copyright © 2008 AGA Institute Terms and Conditions