A New “Spin” on Recovery after Spinal Cord Injury

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A New “Spin” on Recovery after Spinal Cord Injury Andrea Tedeschi, Frank Bradke Cell Volume 159, Issue 7, Pages 1494-1496 (December 2014) DOI: 10.1016/j.cell.2014.12.014 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Promoting Neuroplasticity and Recovery after Spinal Cord Injury (A) Muscle spindles are sensory organs located in skeletal muscles that receive innervation by specialized motor (efferent) and sensory (afferent) axons. Proprioceptive sensory axons originating from dorsal root ganglia (DRG) neurons spiral around the central region of the intrafusal fibers and respond to fiber stretch. The contractile regions of intrafusal fibers receive innervation by gamma motor neurons. (B) Muscle spindle feedback promotes neuroplasticity and functional recovery after incomplete spinal cord injury. Absence of muscle spindle inputs in Egr3 mutant mice results in impaired neuroplasticity and lack of recovery. Cell 2014 159, 1494-1496DOI: (10.1016/j.cell.2014.12.014) Copyright © 2014 Elsevier Inc. Terms and Conditions