Helicobacter pylori: Controversies and an Approach to Management JoANN E. ORMAND, M.D., NICHOLAS J. TALLEY, M.B., Ph.D.  Mayo Clinic Proceedings  Volume 65, Issue 3, Pages 414-426 (March 1990) DOI: 10.1016/S0025-6196(12)62541-5 Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Scanning electron micrograph, demonstrating a spiral-shaped Helicobacter pylori organism along with a curved and coccoid form. (×25,000.) (From Bode and associates.7 By permission of Norwegian University Press.) (Photograph courtesy of Dr. Peter Malfertheiner.) Mayo Clinic Proceedings 1990 65, 414-426DOI: (10.1016/S0025-6196(12)62541-5) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 a, Electron micrograph, showing Helicobacter pylori in close approximation to the gastric epithelium (arrows). (×18,000.) b and c, H. pylori forming an adhesion to a surface mucous cell (arrows). (×114,000.) (Part c from Bode and associates.7 By permission of Norwegian University Press.) (Photograph courtesy of Dr. Peter Malfertheiner.) Mayo Clinic Proceedings 1990 65, 414-426DOI: (10.1016/S0025-6196(12)62541-5) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Photomicrograph of a Warthin-Starry silver-stained gastric biopsy specimen, showing numerous Helicobacter pylori organisms (arrows). (×160.) Mayo Clinic Proceedings 1990 65, 414-426DOI: (10.1016/S0025-6196(12)62541-5) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Ranges and means of reported Helicobacter pylori prevalence rates in various gastroduodenal entities. Eosinophilic = eosinophilic gastritis; Crohn's = Crohn's gastritis; Ménétrier's = Ménétrier's disease; PA = pernicious anemia; Normal = histologically normal gastric mucosa; Gastric Ca = gastric adenocarcinoma; NUD = nonulcer dyspepsia; GU = gastric ulcer (benign); Nonsp gastritis = chronic nonspecific gastritis; DU = duodenal ulcer. Mayo Clinic Proceedings 1990 65, 414-426DOI: (10.1016/S0025-6196(12)62541-5) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 5 Helicobacter pylori prevalence rates plotted by age in three industrialized nations (United Kingdom [UK],54 United States [USA],53 and New Zealand55) and one nonindustrialized nation (Algeria62). Mayo Clinic Proceedings 1990 65, 414-426DOI: (10.1016/S0025-6196(12)62541-5) Copyright © 1990 Mayo Foundation for Medical Education and Research Terms and Conditions