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Association Between Ipilimumab and Celiac Disease

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Presentation on theme: "Association Between Ipilimumab and Celiac Disease"— Presentation transcript:

1 Association Between Ipilimumab and Celiac Disease
Nicole M. Gentile, MD, Anita D'Souza, MBBS, Larissa L. Fujii, MD, Tsung-Teh Wu, MD, PhD, Joseph A. Murray, MD  Mayo Clinic Proceedings  Volume 88, Issue 4, Pages (April 2013) DOI: /j.mayocp Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

2 Figure 1 Biopsy specimen of the colon showing fragments of colonic mucosa with increased crypt apoptosis (arrows) and mild crypt distortion (hematoxylin-eosin, ×200). Mayo Clinic Proceedings  , DOI: ( /j.mayocp ) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

3 Figure 2 Biopsy specimen of the duodenum showing a malabsorptive pattern with partial to near-total villous atrophy, crypt hyperplasia, and chronic inflammation, with a decreased number of Paneth cells (hematoxylin-eosin, ×200). Mayo Clinic Proceedings  , DOI: ( /j.mayocp ) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

4 Figure 3 CD3 immunostain of the duodenal biopsy specimen showing intraepithelial lymphocytosis (×200). Mayo Clinic Proceedings  , DOI: ( /j.mayocp ) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions


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