When monocyte life hangs by a thread

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Presentation transcript:

When monocyte life hangs by a thread by Eric Solary Blood Volume 119(12):2699-2700 March 22, 2012 ©2012 by American Society of Hematology

Autophagy in monocyte-derived cells. Autophagy in monocyte-derived cells. Monocytes are plastic cells that differentiate into M1-polarized macrophages on exposure to GM-CSF and M2-polarized macrophages on M-CSF exposure. Zhang et al report that autophagy is required for monocyte differentiation into macrophages and prevents cell death. Autophagy is also activated in monocytes exposed to GM-CSF and IL-4 to generate dendritic cells,1 and to MCP1 to generate pre-osteoclasts.9 In addition, autophagy is activated in lipid-loaded macrophages (foam cells) found in atherosclerotic lesions10 and in some infected macrophages to favor pathogen elimination and antigen presentation (not shown). Professional illustration by Alice Y. Chen. Eric Solary Blood 2012;119:2699-2700 ©2012 by American Society of Hematology