Finding Shangri-La: Limiting the Impact of Senescence on Aging

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Presentation transcript:

Finding Shangri-La: Limiting the Impact of Senescence on Aging Sally E. Trabucco, Hong Zhang Cell Stem Cell Volume 18, Issue 3, Pages 305-306 (March 2016) DOI: 10.1016/j.stem.2016.02.002 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Targeting Senescence to Delay Aging and Prevent Age-Associated Diseases Inhibition of anti-apoptotic proteins leads to selective killing of senescent cells, whereas suppression of JAK results in inhibition of SASP. Both strategies rejuvenate aged stem cells and improve tissue functions in old mice. HSC, hematopoietic stem cell; MuSC, muscle stem cell; SASP, senescence-associated secretory phenotype. Cell Stem Cell 2016 18, 305-306DOI: (10.1016/j.stem.2016.02.002) Copyright © 2016 Elsevier Inc. Terms and Conditions