1. ADARs Edit MicroRNAs to Promote Leukemic Stem Cell Activity
Wen Cai Zhang, Frank J. Slack 
Cell Stem Cell 
Volume 19, Issue 2, Pages (August 2016)
DOI: /j.stem
Copyright © 2016 Elsevier Inc. Terms and Conditions

2. Figure 1
ADAR1 Transforms Progenitors into Leukemia Stem Cells via Regulating RNA Editing Activity
ADAR1 inhibition by 8-Aza limits LSCs self-renewal capacity via editing of microRNA let-7 biogenesis and the LIN28B/let-7 axis. The functional inhibition of ADAR by 8-Aza is synergistic with tyrosine kinase inhibitors (TKIs) against the JAK2 and BCR-ABL1 oncogenes.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2016 Elsevier Inc. Terms and Conditions