Martin Wahlestedt, David Bryder Cell Stem Cell

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Presentation transcript:

Induced Hematopoietic Stem Cells: Unlocking Restrictions in Lineage Potential and Self-renewal Martin Wahlestedt, David Bryder Cell Stem Cell Volume 14, Issue 5, Pages 555-556 (May 2014) DOI: 10.1016/j.stem.2014.04.008 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Induced Hematopoietic Stem Cells The development of all blood cells originates from multipotent and self-renewing HSCs in the bone marrow. Upon differentiation, the developmental plasticity for all different blood cell lineages is gradually lost and blood cell precursors become “locked” to individual blood cell lineages. Recently in Cell, Riddell et al. (2014) find that the introduction of a set of HSC-associated transcription factors into lineage-committed blood cells can unlock their fate options and reprogram them into induced HSCs that harbor all properties of bona fide HSCs, including multilineage differentiation and self-renewal potential. HSC, hematopoietic stem cell. Cell Stem Cell 2014 14, 555-556DOI: (10.1016/j.stem.2014.04.008) Copyright © 2014 Elsevier Inc. Terms and Conditions