Safety of Proton Pump Inhibitor Exposure

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Safety of Proton Pump Inhibitor Exposure Yu–Xiao Yang, David C. Metz Gastroenterology Volume 139, Issue 4, Pages 1115-1127 (October 2010) DOI: 10.1053/j.gastro.2010.08.023 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Publications that have examined the side effects of PPIs since the release of omeprazole. *Number of articles was calculated based on a PubMed search and then individually selected based on relevance. The PubMed Search terms were ”proton pump inhibitor” OR ”pantoprazole” OR ”lansoprazole” OR ”omeprazole” OR ”esomeprazole” OR ”rabeprazole” AND safety OR adverse events OR risk AND Humans (MeSH) AND English (lang). Gastroenterology 2010 139, 1115-1127DOI: (10.1053/j.gastro.2010.08.023) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Potential pathways through which PPI therapy can decrease bone strength. VBMD, volumetric bone mineral density; PTH, parathyroid hormone. Gastroenterology 2010 139, 1115-1127DOI: (10.1053/j.gastro.2010.08.023) Copyright © 2010 AGA Institute Terms and Conditions