Steven A. Sloan, Ben A. Barres Neuron

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Looks Can Be Deceiving: Reconsidering the Evidence for Gliotransmission Steven A. Sloan, Ben A. Barres Neuron Volume 84, Issue 6, Pages 1112-1115 (December 2014) DOI: 10.1016/j.neuron.2014.12.003 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Original and New Interpretations of dnSNARE Mice Phenotypes (A) Schematic (A) depicts the interpretation of dnSNARE mice with the presumption that transgene expression is restricted to astrocytes. In the presence of Dox, tetO-mediated dnSNARE expression is repressed in all cells. In the Off-Dox condition, however, astrocytic vesicular transmitter release is inhibited, and a subsequent reduction in EEG power is observed. These observations suggest that astrocyte gliotransmitter release contributes to baseline neural activity. However, the EEG power suppression in absence of Dox is more potent than it would be expected based on prior reports on gliotransmission. (B) In scenario (B), new data demonstrate that suppression of EEG power is the result of direct inhibition of exocytosis of synaptic vesicles as a consequence of leaky dnSNARE expression in neurons. Neuron 2014 84, 1112-1115DOI: (10.1016/j.neuron.2014.12.003) Copyright © 2014 Elsevier Inc. Terms and Conditions