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Have You Heard? Viral-Mediated Gene Therapy Restores Hearing

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1 Have You Heard? Viral-Mediated Gene Therapy Restores Hearing
Donna M. Martin, Yehoash Raphael  Neuron  Volume 75, Issue 2, Pages (July 2012) DOI: /j.neuron Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Cartoon Showing the Organ of Corti Inner and Outer Hair Cells
The typical inner hair cell connects to auditory nerve fibers and depolarizes them by releasing glutamate upon sound activation. Shown to the right of the hair cell are schematic drawings of the ribbon synapse as seen by electron microscopy. In Vglut3 mutant mice, VGLUT3 is absent, the ribbon and neurotransmitter vesicles appear pathological (the ribbon is flat and vesicles are elongated), and hearing is impaired (the musical notes depict hearing ability or lack thereof). In Vglut3 mutant mice treated with AAV1-mediated Vglut3 gene transfer, VGLUT3 can be detected in inner hair cells, and both the ribbon and the vesicles more closely resemble the normal morphology. Mice treated with AAV-Vglut3 exhibit normal hearing thresholds as measured by electrophysiology and also exhibit hearing using behavioral assays. Neuron  , DOI: ( /j.neuron ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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