Spotlight on Immuno-Oncology in Melanoma
Introduction
Emerging Agents Epacadostat
Emerging Agents (cont) Epacadostat
Emerging Agents OX40
Emerging Agents (cont) OX40 Antibody
Emerging Agents 4-1BB
Emerging Agents 4-1BB Antibody
Emerging Agents LAG-3
Practical Implications of These Emerging Agents
Pembrolizumab Survival Updates KEYNOTE-001
Pembrolizumab Survival Updates KEYNOTE-006
Notes on Stopping Therapy
Combination Nivolumab/Ipilimumab Survival Updates CheckMate-067
Upfront Treatment
Combination Nivolumab/Ipilimumab Survival Updates CheckMate-069
Are Some Patients Cured with Immunotherapy?
Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs
Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs (cont)
Treating Brain Metastases
Thoughts on Treating Brain Metastases
Sequencing Therapy
irAEs and Potential Treatment Benefit
Discontinuing Treatment Due to AEs
AEs and Treatment Benefit
Practical Applications
Patients With Wild-Type Disease That Progresses With Immunotherapy
A Look to the Future
Concluding Remarks
Abbreviations
Abbreviations (cont)