Spotlight on Immuno-Oncology in Melanoma

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Presentation transcript:

Spotlight on Immuno-Oncology in Melanoma

Introduction

Emerging Agents Epacadostat

Emerging Agents (cont) Epacadostat

Emerging Agents OX40

Emerging Agents (cont) OX40 Antibody

Emerging Agents 4-1BB

Emerging Agents 4-1BB Antibody

Emerging Agents LAG-3

Practical Implications of These Emerging Agents

Pembrolizumab Survival Updates KEYNOTE-001

Pembrolizumab Survival Updates KEYNOTE-006

Notes on Stopping Therapy

Combination Nivolumab/Ipilimumab Survival Updates CheckMate-067

Upfront Treatment

Combination Nivolumab/Ipilimumab Survival Updates CheckMate-069

Are Some Patients Cured with Immunotherapy?

Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs

Treating Patients Who Had Autoimmune Disorders or Preexisting irAEs (cont)

Treating Brain Metastases

Thoughts on Treating Brain Metastases

Sequencing Therapy

irAEs and Potential Treatment Benefit

Discontinuing Treatment Due to AEs

AEs and Treatment Benefit

Practical Applications

Patients With Wild-Type Disease That Progresses With Immunotherapy

A Look to the Future

Concluding Remarks

Abbreviations

Abbreviations (cont)