Volume 46, Issue 3, Pages (September 2004)

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Volume 46, Issue 3, Pages 403-407 (September 2004) Intracavernosal Injection of Vascular Endothelial Growth Factor Improves Erectile Function in Aged Rats Kwangsung Park, Kyu Youn Ahn, Min-Kyung Kim, Song Eun Lee, Taek Won Kang, Soo-Bang Ryu European Urology Volume 46, Issue 3, Pages 403-407 (September 2004) DOI: 10.1016/j.eururo.2004.04.032

Fig. 1 Volumetric densities of corpus cavernosum smooth muscle in rat penis. Sections were stained with Masson’s trichrome. Values represent mean ± S.D. with 5 rats in each group. (A) Young rats, (B) old vehicle-only rats, (C) old rats + VEGF (1μg at 2 weeks), (D) old rats + VEGF (10μg at 2 weeks), (E) old rats + VEGF (1μg at 4 weeks), (F) old rats + VEGF (10μg at 4 weeks). ∗Compared to young control rats (p = 0.047). †Compared to old vehicle only rats (p = 0.047). European Urology 2004 46, 403-407DOI: (10.1016/j.eururo.2004.04.032)

Fig. 2 Representative photomicrographs of rat penile shaft sections immunohistochemically stained for e-NOS (A, B, C, D) or VEGF (E, F, G, H) in young rat (A, E), old vehicle-only rat (B, F), old rat + VEGF (1μg at 4 weeks) (C, G), old rat + VEGF (10μg at 4 weeks) (D, H). In young rats, there was moderate immunoreactivity to both e-NOS and VEGF in endothelial lining (arrows), while weak immunoreactivities were observed in old vehicle-only rats. Intracavernous VEGF treatment in old rats augmented e-NOS and VEGF expression in both the 1μg/kg VEGF and the 10μg/kg VEGF treatment groups at 4 weeks. Scale bar = 50μm. European Urology 2004 46, 403-407DOI: (10.1016/j.eururo.2004.04.032)