Stage 10 Human Embryo (~ 22 Days)

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Presentation transcript:

Stage 10 Human Embryo (~ 22 Days)

Somite Formation from Pre-Somitic Mesoderm

Somite Formation and Hairy Gene expression

Hairy Gene Expression

Homeotic (Hox) Genes Hox a Hox b Hox c Hox d

Hox Gene Expression Along A/P Axis (Posterior margin of Hox Genes Expression)

“Hox Code” Concept

Hoxc8 Deletion in Mouse

Forelimb Development in chick and mouse

Limb Bud Development

Sonichedgehog (Shh) Expression in Limb Bud

Ectopic Application of Shh Protein

Hox Gene Expression in Limb Bud Hox a genes Hox d genes

Synpolydactyl Phenotype Hoxd13 mutation

Digit Formation Programmed Cell Death

Programmed Cell Death Pathway (BMP?)

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