Feasibility of Reduced-Intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure: Results of a Nationwide Survey of Adult Patients Fusako.

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Feasibility of Reduced-Intensity Cord Blood Transplantation as Salvage Therapy for Graft Failure: Results of a Nationwide Survey of Adult Patients Fusako Waki, Kazuhiro Masuoka, Takahiro Fukuda, Yoshinobu Kanda, Mika Nakamae, Kimikazu Yakushijin, Katsuhiro Togami, Kaichi Nishiwaki, Yasunori Ueda, Fumio Kawano, Masaharu Kasai, Koji Nagafuji, Maki Hagihara, Kazuo Hatanaka, Masafumi Taniwaki, Yoshinobu Maeda, Naoki Shirafuji, Takehiko Mori, Atae Utsunomiya, Tetsuya Eto, Hitoshi Nakagawa, Makoto Murata, Toshiki Uchida, Hiroatsu Iida, Kazuaki Yakushiji, Takuya Yamashita, Atsushi Wake, Satoshi Takahashi, Yoichi Takaue, Shuichi Taniguchi Biology of Blood and Marrow Transplantation Volume 17, Issue 6, Pages 841-851 (June 2011) DOI: 10.1016/j.bbmt.2010.09.005 Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of neutrophil engraftment. (A) The cumulative incidences of neutrophil engraftment (solid line) and death without engraftment (dotted line) are shown. (B) The cumulative incidence of neutrophil engraftment was higher in patients who received alkylating agent–containing regimen (solid line) than in those who did not (dotted line) (P = .0001). (C) The cumulative incidence of neutrophil engraftment was higher in patients who received graft containing TNC ≥2.5 × 107/kg than in those who did not (P = .01). Biology of Blood and Marrow Transplantation 2011 17, 841-851DOI: (10.1016/j.bbmt.2010.09.005) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Cumulative incidence of transplantation-related mortality (TRM) and relapse. (A) The cumulative incidences of TRM (solid line) and relapse (dotted line) are shown. (B) The cumulative incidence of TRM was higher in patients who had grade 3 or 4 carryover organ toxicity before the second SCT (solid line) than in those who did not (dotted line) (P = .03). Biology of Blood and Marrow Transplantation 2011 17, 841-851DOI: (10.1016/j.bbmt.2010.09.005) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 OS and PFS. (A) The Kaplan-Meier estimates of OS (solid line) and PFS (dotted line) are shown. (B) OS in patients who were high risk at the first SCT (dotted line) was lower than that in those who were standard risk (solid line) (P = .003). Biology of Blood and Marrow Transplantation 2011 17, 841-851DOI: (10.1016/j.bbmt.2010.09.005) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions