World Epidemiology. Are HIV and Other Chronic Diseases Models Applicable to Viral Hepatitis? Focus on HCV.

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Presentation transcript:

Are HIV and Other Chronic Diseases Models Applicable to Viral Hepatitis? Focus on HCV

World Epidemiology

HCV Epidemiology

HCV Subtype Distribution: A Mosaic of Overlapping Sub-Epidemics

HIV-1 Subtypes Worldwide

U.S. Epidemiology

HCV and HIV in the US

HIV/HCV in the U.S.: Epidemiological Overlap

Prevalence of HCV Ab by Demographic Characteristics 1999-2002 NHANES

Relative Importance of Risk Factors for Remote and Recent HCV Infection

Testing and Care

Current Recs for HCV Testing

U.S.: New HIV Infections / Year

HCV infection in the U.S.

CDC Medical Monitoring Project: HIV Update

Virology

Viral Genetic Diversity

Life Cycle of HIV

HCV and HIV Polymerases: Similar Structure and Function

HCV and HIV Proteases

Virology: Summary

Natural History

HIV and HCV: Much in Common

HCV: Natural History

Natural History of HIV Infection

Age-Adjusted HCV Mortality: 1995-2005

Treatment

Assessing Virologic Response in HCV Therapy

HIV Therapy: 1987-1996

HCV Protease Inhibitors

Independent Predictors of Sustained Virologic Response (Logistic Regression)

HIV Drug Approval: 1987 - 2012

ART: 1997-2006

HIV Drug Approval: 1987 - 2012

HIV Drug-Resistance Testing

HIV Cure (N=1)

HCV and HIV: Treatment Issues

HCV + HIV: Healthcare Team

HCV and HIV: Summary

Acknowledgments

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