Bone Morphogenetic Proteins

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Bone Morphogenetic Proteins 11/16/2018 Bone Morphogenetic Proteins Signal Sequence N Pro-domain Mature Domain C Proteolytic cleavage C C Folding & dimerization C Active BMP dimer BMP: bone morphogenetic protein (osteogenin) C: cysteine Eric Niederhoffer SIU-SOM

BMP Signaling Pathways 11/16/2018 BMP Signaling Pathways C C C GS box Smad pathway MAPK pathway (s) Type II receptor Type I receptor BMP: bone morphogenetic protein (osteogenin) GS box: glycine-serine protein motif MAPK: mitogen-activated protein kinase (mitogen = mitosis-stimulating growth factors) Smad: Caenorhabditis elegans “Sma” mothers against decapentaplegic Target gene