Mismatch on Glutathione S-Transferase T1 Increases the Risk of Graft-versus-Host Disease and Mortality after Allogeneic Stem Cell Transplantation María.

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Mismatch on Glutathione S-Transferase T1 Increases the Risk of Graft-versus-Host Disease and Mortality after Allogeneic Stem Cell Transplantation María José Martínez-Bravo, Cristina Calderón-Cabrera, Francisco José Márquez-Malaver, Nancy Rodríguez, Marta Guijarro, Idelfonso Espigado, Antonio Núñez-Roldán, José Antonio Pérez-Simón, Isabel Aguilera Biology of Blood and Marrow Transplantation Volume 20, Issue 9, Pages 1356-1362 (September 2014) DOI: 10.1016/j.bbmt.2014.05.008 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 GSTT1 disparity is a risk factor for acute GVHD. This figure illustrates the cumulative incidence of different events between GSTT1-mismatched versus GSTT1-matched recipients. In all the cases, the differences are statistically significant: (A) grades 2 to 4 acute GVHD (P = .048); (B) grades 3 to 4 acute GVHD (P = .004); (C) grades 2 to 4 liver acute GVHD (<.001); and (D) grades 3 to 4 liver acute GVHD (P < .001). Biology of Blood and Marrow Transplantation 2014 20, 1356-1362DOI: (10.1016/j.bbmt.2014.05.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 GSTT1 disparity is a risk factor for chronic GVHD. This figure shows the cumulative incidence of (A) chronic GVHD between GSTT1-mismatched versus GSTT1-matched recipients (P = .038) and (B) chronic GVHD in its liver presentation (P = .006). Biology of Blood and Marrow Transplantation 2014 20, 1356-1362DOI: (10.1016/j.bbmt.2014.05.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) NRM after 3 years was 52.6% for GSTT1-mismatched patients versus 26.8% for GSTT1-matched recipients (P = .031); (B) GSTT1-mismatch condition is related to a lower surveillance after allo-HSCT. Survival, 3 years after the transplantation, was 62% for GSTT1-matched versus 36.9% for mismatched patients (P = .045). Biology of Blood and Marrow Transplantation 2014 20, 1356-1362DOI: (10.1016/j.bbmt.2014.05.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions